proINDY

Chemical Structure : proINDY

Catalog No.: PC-22437Not For Human Use, Lab Use Only.

proINDY is the acetylated derivative prodrug of INDY, which is a potent, selective and ATP-competitive inhibitor of Dyrk1A, effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression.

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Biological Activity

Physicochemical Properties

M.Wt	277.34
Formula	C14H15NO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-ethyl-2-(2-oxopropylidene)-2,3-dihydrobenzo[d]thiazol-5-yl acetate

References

1. Masaki S, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4434-4441.

2. Ogawa Y, et al. Nat Commun. 2010 Oct 5;1:86.

3. MacDonald J, et al. Mol Cancer Res. 2017 Apr;15(4):371-381.

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proINDY

Biological Activity

Physicochemical Properties

References

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