sPLA2-X inhibitor 31 |CAS: 2241025-50-1 Probechem Biochemicals

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Chemical Structure : sPLA2-X inhibitor 31

sPLA2-X inhibitor 31

Catalog No.: PC-35307Not For Human Use, Lab Use Only.

sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively.
sPLA2-X inhibitor 31 demonstrates improved lipolitic activity of sPLA2-X on HDL (IC50=270 nM), does not display any significant binding to a large panel of biological targets and no significant inhibition of ion channels, enzymes and transporters that might be related to toxicity

Physicochemical Properties

M.Wt	392.334
Formula	C19H15F3N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(2-carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl)phenyl)propanoic acid

References

1. Knerr L, et al. ACS Med Chem Lett. 2018 Jun 23;9(7):594-599.

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