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Chemical Structure : sRANKL inhibitor S3-15
Catalog No.: PC-49334Not For Human Use, Lab Use Only.
sRANKL inhibitor S3-15 is a highly potent, orally active inhibitor of soluble RANKL, selectively interrupt soluble RANKL-RANK interaction and without interfering with the membrane RANKL-RANK interaction, shows potent osteoclast inhibition effect with IC50 of 0.19 uM in vitro.
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sRANKL inhibitor S3-15 is a highly potent, orally active inhibitor of soluble RANKL, selectively interrupt soluble RANKL-RANK interaction and without interfering with the membrane RANKL-RANK interaction, shows potent osteoclast inhibition effect with IC50 of 0.19 uM in vitro.
S3-15 can bind to sRANKL at the enlarged stable region (binding site), and unable to bind to mRANKL at the shrunken stable region.
S3-15 inhibits sRANKL induced osteoclast differentiation, while exhibits weak osteoclast differentiation in mRANKL induced osteoclastogenesis assay.
S3-15 suppresses RANKL-induced NF-κB signaling by decreasing the phosphorylation of the IκB kinase-α (IKKα), NF-κB inhibitor-α (IκBα) and p65.
S3-15 dose-dependently blocked both downstream transcription factor NF-κB and NFATC luciferase reporter-gene expression of RANKL-RANK signaling.
S3-15 selectively inhibits sRANKL without changing T lymphocyte differentiation.
S3-15 exhibits anti-osteoporotic effects without causing immunosuppression in ovariectomy (OVX) rats.
| M.Wt | 326.312 | |
| Formula | C16H14N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang D, et al. Nat Commun. 2022 Sep 12;13(1):5338.
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