Chemical Structure : slCeMM1
CAS No.:
949973-22-2
slCeMM1
Catalog No.: PC-20896Not For Human Use, Lab Use Only.
slCeMM1 is a potent, highly selective inhibitor of lactate transporter SLC16A3 (MCT4), inhibits intracellular lactate accumulation in SLC16A3 dependent cells (IC50=91 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
slCeMM1 is a potent, highly selective inhibitor of lactate transporter SLC16A3 (MCT4), inhibits intracellular lactate accumulation in SLC16A3 dependent cells (IC50=91 nM).
slCeMM1 displays no effec on intracellular lactate accumulationt in cells dependent on SLC16A1.
slCeMM1 inhibits growth of HAP1 cells dependent on SLC16A3 (IC50 = 0.88 μM), but not on SLC16A1, SLC16A7 or SLC16A8, and this effect was rescued by re-introduction of SLC16A1WT but not transport-deficient mutant SLC16A1R313Q.
slCeMM1 is a valuable additional tool that helps to chemically validate SLC16A3 as a target based on experiments with gene knock-out/knock-down strategies.
Physicochemical Properties
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M.Wt
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414.39
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Formula
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C20H17F3N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(NC1=CC2=CC=CC=C2N=C1)CCC3=C(C)N4C(N=C3C)=NC(C(F)(F)F)=N4
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References
1. Dvorak V, et al. Cell Chem Biol. 2023 Jul 15:S2451-9456(23)00204-0.
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