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Chemical Structure : trans-ISRIB
CAS No.: 1597403-47-8
Catalog No.: PC-43062Not For Human Use, Lab Use Only.
ISRIB trans-isomer is a potent inhibitor of PERK signaling, potently reverses the effects of eIF2α phosphorylation with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | Get quote |
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trans-ISRIB is a potent inhibitor of PERK signaling, potently reverses the effects of eIF2α phosphorylation with IC50 of 5 nM.
ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, display significant enhancement in spatial and fear-associated learning.
ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR), 100-fold more potent than cis-ISRIB (IC50=600 nM).
| M.Wt | 451.343 | |
| Formula | C22H24Cl2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 38 mg/mL |
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| Chemical Name/SMILES |
Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)- |
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1. Sidrauski C, et al. Elife. 2013 May 28;2:e00498.
2. Sidrauski C, et al. Elife. 2015 Feb 26;4.
3. Halliday M, et al. Cell Death Dis. 2015 Mar 5;6:e1672.
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