trans-ISRIB is a potent inhibitor of PERK signaling, potently reverses the effects of eIF2α phosphorylation with IC50 of 5 nM.
ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, display significant enhancement in spatial and fear-associated learning.
ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR), 100-fold more potent than cis-ISRIB (IC50=600 nM).
