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z-FA-FMK

Chemical Structure : z-FA-FMK

CAS No.: 197855-65-5

z-FA-FMK ((1S)-Z-FA-FMK)

Catalog No.: PC-25489Not For Human Use, Lab Use Only.

Z-FA-FMK ((1S)-Z-FA-FMK) is a potent cathepsin B and cathepsin L inhibitor, inhibits caspase activity in vitro and selectively inhibits recombinant effector caspases 2, -3, -6, and -7, but not caspases 8 and 10.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Z-FA-FMK ((1S)-Z-FA-FMK) is a potent cathepsin B and cathepsin L inhibitor, inhibits caspase activity in vitro and selectively inhibits recombinant effector caspases 2, -3, -6, and -7, but not caspases 8 and 10.

Physicochemical Properties

M.Wt 386.42
Formula C21H23FN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzyl ((2S)-1-((4-fluoro-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

References

1. Schotte P, et al. J Biol Chem. 2001 Jun 15;276(24):21153-7.

2. Lopez-Hernandez FJ, et, al. Mol Cancer Ther. 2003 Mar;2(3):255-63.

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