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ztz240

Chemical Structure : ztz240

CAS No.: 325457-98-5

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ztz240 (ztz-240)

Catalog No.: PC-26104Not For Human Use, Lab Use Only.

ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels.

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10 mg $398 In stock
25 mg $598 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels.
ztz240 binds to the open-state voltage-sensor domain (VSD).
ztz240 exhibits significant anti-epilepsy activity on mouse PTZ-induced seizure model.

Physicochemical Properties

M.Wt 250.66
Formula C12H8ClFN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-chloro-pyridin-3-yl)-4-fluorobenzamide

References

1. Li P, et al. Cell Res. 2013 Sep;23(9):1106-18.

2. Li X, et al. Cell Res. 2021 Jan;31(1):52-61.

3. Zhaobing Gao, et al. J Biol Chem. 2010 Sep 3;285(36):28322-32.

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