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α7nAChR PAM 28

Chemical Structure : α7nAChR PAM 28

CAS No.: 1394371-75-5

α7nAChR PAM 28 (α7nAChR positive allosteric modulator 28)

Catalog No.: PC-38317Not For Human Use, Lab Use Only.

α7nAChR PAM 28 is a novel potent, brain-permeable, orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) with EC50 of 0.32 uM.

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Biological Activity

α7nAChR PAM 28 is a novel potent, brain-permeable, orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) with EC50 of 0.32 uM.
α7 nAChR PAM 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels.

Physicochemical Properties

M.Wt 419.938
Formula C20H18ClNO3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Month
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

References

1. Neelima Sinha, et al. J Med Chem. 2020 Feb 13;63(3):944-960.

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