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Chemical Structure : α7nAChR PAM 28
CAS No.: 1394371-75-5
Catalog No.: PC-38317Not For Human Use, Lab Use Only.
α7nAChR PAM 28 is a novel potent, brain-permeable, orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) with EC50 of 0.32 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $358 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | $958 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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α7nAChR PAM 28 is a novel potent, brain-permeable, orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) with EC50 of 0.32 uM.
α7 nAChR PAM 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels.
| M.Wt | 419.938 | |
| Formula | C20H18ClNO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide |
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1. Neelima Sinha, et al. J Med Chem. 2020 Feb 13;63(3):944-960.
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