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Chemical Structure : γ-secretase modulator 14a
Catalog No.: PC-60155Not For Human Use, Lab Use Only.
A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM.
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A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM; shows good to excellent selectivity for the reduction of Aβ42 in the cellular assays; significantly reduces Aβ42 in the CNS compartment in vivo in nontransgenic rat models.
| M.Wt | 418.472 | |
| Formula | C24H23FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhao Z, et al. ACS Med Chem Lett. 2017 Sep 19;8(10):1002-1006.
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