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β-catenin-IN-37

Chemical Structure : β-catenin-IN-37

CAS No.: 1783856-40-5

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β-catenin-IN-37

Catalog No.: PC-61802Not For Human Use, Lab Use Only.

β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM.
    β-catenin-IN-37 suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes.
    β-catenin-IN-37 inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively.

    Physicochemical Properties

    M.Wt 307.277
    Formula C13H9N9O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(2-(2H-Tetrazol-5-yl)ethyl)-5H-[1,2,5]oxadiazolo[3',4':5,6]-pyrazino[2,3-b]indole

    References

    1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92.

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