β-catenin degrader EN83 | β-catenin degrader

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Chemical Structure : β-catenin degrader EN83

β-catenin degrader EN83 (CTNNB1 degrader EN83)

Catalog No.: PC-22500Not For Human Use, Lab Use Only.

β-catenin degrader EN83 is a covalent degrader of β-catenin (CTNNB1), depletes CTNNB1 in a ubiquitin-proteasome-dependent manner.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

β-catenin degrader EN83 is a covalent degrader of β-catenin (CTNNB1), depletes CTNNB1 in a ubiquitin-proteasome-dependent manner.
EN83 directly and covalently targets CTNNB1 three cysteines C466, C520, and C619, leading to destabilization and degradation of CTNNB1.
EN83 inhibits CTNNB1 transcriptional activity, demonstrating functional inhibition of the WNT pathway in cells.
EN83 treatment significantly reduced the levels of CTNNB1 target gene MYC.

Physicochemical Properties

M.Wt	283.75
Formula	C14H18ClNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-1-(2-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)ethan-1-one

References

1. Gowans FA, et al. J Am Chem Soc. 2024 Jun 6. doi: 10.1021/jacs.4c05174.

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β-catenin degrader EN83 (CTNNB1 degrader EN83)

Biological Activity

Physicochemical Properties

References

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