ζ-Stat |CAS:3316-02-7 Probechem Biochemicals

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Chemical Structure : ζ-Stat

CAS No.: 3316-02-7

ζ-Stat (NSC37044, PKC-zeta inhibitor, Zeta-Stat)

Catalog No.: PC-35337Not For Human Use, Lab Use Only.

ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, shows only 13% inhibition on PKC-I at 20 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, shows only 13% inhibition on PKC-I at 20 uM.
ζ-Stat downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
ζ-Stat significantly decreases melanoma cell proliferation of SK-MEL-2 and MeWo.

Physicochemical Properties

M.Wt	384.344
Formula	C10H8O10S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-hydroxy-1,3,6-naphthalenetrisulfonic acid

References

1. Islam SMA, et al. Biochim Biophys Acta. 2018 Apr;1865(4):650-664.

2. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.

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ζ-Stat (NSC37044, PKC-zeta inhibitor, Zeta-Stat)

Biological Activity

Physicochemical Properties

References

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