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Chemical Structure : (-)-GSK598809
CAS No.: 863680-46-0
Catalog No.: PC-49576Not For Human Use, Lab Use Only.
GSK598809 (GSK-598809) is a potent, selective dopamine D(3) receptor antagonist with Ki value of 6.2 nM, >100-fold selectivity over D2 receptor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $368 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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GSK598809 (GSK-598809) is a potent, selective dopamine D(3) receptor antagonist with Ki value of 6.2 nM, >100-fold selectivity over D2 receptor.
GSK598809 increased the hemodynamic effect of cocaine on hemodynamics and cardiac function in freely-moving, telemetered dogs.
GSK598809 selectively enhanced neural response during monetary reward anticipation in drug and acohol dependence.
| M.Wt | 481.51 | |
| Formula | C22H23F4N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(5-((3-((1S,5R)-1-(2-fluoro-4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-3-yl)propyl)thio)-4-methyl-4H-1,2,4-triazol-3-yl)-4-methyloxazole |
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1. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.
2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.
3. Mugnaini M, et al. Neuropsychopharmacology. 2013 Jan;38(2):302-12.
4. Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine
receptors. Patent Cooperation Treaty (PCT) International Publication
WO2005/080382 poS.
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