Catalog No.: PC-72176Not For Human Use, Lab Use Only.
(–)-IHCH7041 is a potent, selective partial agonist at DRD2/3 and 5-HT1AR, with EC50 of 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment assays, with negligible 5-HT2AR binding (>100-fold selectivity).
(–)-IHCH7041 is a potent, selective partial agonist at DRD2/3 and 5-HT1AR, with EC50 of 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment assays, with negligible 5-HT2AR binding (>100-fold selectivity).
(–)-IHCH7041 exhibits negligible affinities for a large number of tested GPCRs, ion channels and transporters (Ki>500 nM), good affinities for DRD2 and DRD3 (Ki=14.42 nM), and moderate binding to 5-HT1A (Ki=60.62 nM).
(–)-IHCH7041 behaves as a partial agonist in both G-protein signaling and β-arrestin recruitment activities at DRD2, DRD3 and 5-HT1AR.
(–)-IHCH7041 displayed potent antipsychotic activity and has antidepressant properties and reverses cognitive impairmentin mice.
Physicochemical Properties
M.Wt
184.283
Formula
C10H20N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,1-dimethyl-3-((1r,4r)-4-methylcyclohexyl)urea
References
1. Zhangcheng Chen, et al. Nat Neurosci. 2022 Jan;25(1):39-49.
