Catalog No.: PC-21142Not For Human Use, Lab Use Only.
(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.
(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.
(3S) ALG-05 is non-lethal and capable of inhibiting Ec TIL intracellularly.
(3S) ALG-05 displays target engagement with minimal toxicity in cells.
(3S) ALG-05 (140 mg/kg, oral gavage) significantly reduces levels of cecal indole and serum indoxyl sulfate (IS) in C57BL/6 mice.
TILs are pyridoxal 5′-phosphate (PLP)-dependent enzymes that catalyze α,β-elimination and β-replacement reactions to generate pyruvate, ammonia, and indole.
