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Chemical Structure : (3S) ALG-05
Catalog No.: PC-21142Not For Human Use, Lab Use Only.
(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.
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(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.
(3S) ALG-05 is non-lethal and capable of inhibiting Ec TIL intracellularly.
(3S) ALG-05 displays target engagement with minimal toxicity in cells.
(3S) ALG-05 (140 mg/kg, oral gavage) significantly reduces levels of cecal indole and serum indoxyl sulfate (IS) in C57BL/6 mice.
TILs are pyridoxal 5′-phosphate (PLP)-dependent enzymes that catalyze α,β-elimination and β-replacement reactions to generate pyruvate, ammonia, and indole.
| M.Wt | 254.67 | |
| Formula | C11H11ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Amanda L Graboski, et al. Cell Chem Biol. 2023 Aug 12;S2451-9456(23)00244-1.
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