| Cat. No. |
Product Name |
Information |
| PC-27804 |
BSH-IN-1
BSH inhibitor
|
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively. |
| PC-27803 |
BSH inhibitor GR-7
BSH inhibitor
|
BSH inhibitor GR-7 (Gut restricted-7) is a potent, specific, covalent inhibitor of gut bacterial bile salt hydrolase (BSH) with IC50 of 237-1070 nM. |
| PC-27800 |
SMALS-329
LKB1 activator
|
SMALS-329 is a small-molecule activator of liver kinase B1 (LKB1, STK11) via pseudokinase STE20-related kinase adapter protein (STRAD) with EC50 of 8.5 uM (activation 541%), binds ATP pocket of STRADα to activate LKB1. |
| PC-27779 |
Phoenixin-14
GPR173 ligand
|
Phoenixin-14 (PNX-14) is an endogenous neuropeptide with multiple biological activities and endogenous ligand of GPR173. |
| PC-27766 |
PI5P4Kγ inhibitor n40
PI5P4Kγ inhibitor
|
PI5P4Kγ inhibitor n40 is a potent, selective orthosteric-allosteric dual inhibitor of PI5P4Kγ with Kd of 6.55 nM, has >1000-fold selectivity over PI5P4Kα and PI5P4Kβ. |
| PC-27757 |
SLK/STK10-IN-1
SLK/STK10 inhibitor
|
SLK/STK10-IN-1 is a potent, selective dual inhibitor of SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) with IC50 of 1 uM for both in NanoBRET assays in HEK293 cells, shows good kinome-wide selectivity. |
| PC-27755 |
Saikosaponin D
CAS 20874-52-6
|
Saikosaponin D is an active component isolated from Bupleurum falcatum, inhibits activated T lymphocyte proliferation by downregulating the NF-κB, NF-AT, and AP-1 signaling pathways, suppresses enterovirus A71 infection (EV-A71) by inhibiting autophagy, also potently inhibits the proliferation and invasion of cancer cells, induces the apoptosis of cancer cells, and suppresses angiogenesis. |
| PC-27734 |
YS-01
Pendrin inhibitor
|
YS-01 is a potent, specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), potently inhibits pendrin-mediated Cl-/SCN-, Cl-/I-, Cl-/HCO3-, and Cl-/OH- exchange activity in a dose-dependent manner. |
| PC-27733 |
PDSinh-A01
Pendrin inhibitor
|
PDSinh-A01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4) with IC50 of 6.6 uM. |
| PC-27732 |
PDSinh-C01
Pendrin inhibitor
|
PDSinh-C01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), inhibits Cl−/anion exchange mediated by mouse pendrin with IC50 of 1-3 uM, without affecting other major kidney tubule transporters. |
| PC-27728 |
UCB-J
SV2A modulator
|
UCB-J is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A) with pIC50 of 8.15 and 7.6 human and rat SV2A respectively. |
| PC-27727 |
ABBV-552
SV2A modulator
|
ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A). |
