Chemical Structure : VG-3927
CAS No.:
2738485-98-6
VG-3927
(Compiund I-192)
Catalog No.: PC-24792Not For Human Use, Lab Use Only.
VG-3927 (I-192) is a highly potent, selective and brain penetrant triggering receptor expressed on myeloid cells 2 (TREM2) agonist.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VG-3927 (I-192) is a highly potent, selective and brain penetrant triggering receptor expressed on myeloid cells 2 (TREM2) agonist.
VG-3927 promotes TREM2 clustering rather than acting as a direct ligand
VG-3927 promoted anti-inflammatory microglia activation and suppressed a broad spectrum of neurodegeneration-associated biomarkers.
VG-3927 reduced pathological forms of Aβ, insoluble ApoE levels, and peri-plaque dystrophic neurites after 6 weeks of oral dosing in humanized TREM2 plaque-bearing mice.
VG-3927 shows favorably tune human microglia activation and impart a broadly neuroprotective profile across preclinical model systems.
Physicochemical Properties
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M.Wt
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451.93
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Formula
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C24H23ClFN5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-((2R,4S)-2-(1-methyl-1H-pyrazol-4-yl)tetrahydro-2H-pyran-4-yl)pyrido[3,4-b]pyrazine
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References
1. Christian Mirescu, et al. Alzheimers Dement. 2025, 20(Suppl 6), e089318.
2. Hossam Nada, et al. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.
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