| Cat. No. |
Product Name |
Information |
| PC-63467 |
Syn-TEF1 intermediate 1
|
Syn-TEF1 intermediate 1 is a chemcal intermediate for Syn-TEF1 synthesis, which is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia. |
| PC-63457 |
CU239
RPE65 inhibitor
|
CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM. |
| PC-63456 |
ERGi-USU
RIOK2 inhibitor
|
ERGi-USU (NSC 139021) is a specific RIOK2 inhibitor, selectively inhibits ERG-positive cancer cell growth, directly binds (Kd=200 nM) and inhibits RIOK2 protein with IC50 of 220 nM (VCaP) and 360 nM (COLO320). |
| PC-63448 |
LBL1
Lamin A inhibitor
|
LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM). |
| PC-63447 |
Syn-TEF1
Tanscription modualtor
|
Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci. |
| PC-63439 |
PH002
ApoE4 inhibitor
|
PH002 is a small-molecule structure corrector significantly decreased ApoE4 fragment levels in ApoE4/4-hiPSC-derived neurons, increases GABAergic neuron numbers and GAD67 levels, reduces p-tau levels, and decreases Aβ40 and Aβ42 production and/or secretion. |
| PC-63409 |
JNJ-26993135
LTA4H inhibitor
|
JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM. |
| PC-63371 |
Oxythiamine chloride hydrochloride
Transketolase inhibitor
|
Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM. |
| PC-63363 |
TMP-153
ACAT inhibitor
|
TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals. |
| PC-63355 |
Compound-326
D5D/FADS1 inhibitor
|
Compound-326 (D5D inhibitor 326, D5D-IN-326) is apotent, selective, orally active delta-5 desaturase (D5D, FADS1/Fatty Acid Desaturase 1) with IC50 of 72 and 22 nM for rat and human D5D, respectively. |
| PC-63354 |
T-3861174
prolyl tRNA synthetase inhibitor
|
T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM. |
| PC-63336 |
AZ-1355
|
AZ-1355 is an effctive lipid-lowering compound that inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.. |
