| Cat. No. |
Product Name |
Information |
| PC-35109 |
BTZO-15
HO-1 inducer
|
BTZO-15 is an active BTZO-1 derivative for ARE-activation with a favorable ADME-Tox profile, induces expression of heme oxygenase-1 (HO-1) and inhibits NO-induced cell death in IEC-18 cells. |
| PC-35108 |
BTZO-2
MIF activator
|
BTZO-2 is an active BTZO-1 derivative and macrophage migration inhibitory factor (MIF) activator, an antioxidant response element (ARE) activator, provides protection against lethal endotoxic shock in mice. |
| PC-35107 |
BTZO-1
MIF activator, HO-1 inducer
|
BTZO-1 is a cardioprotective agent and Macrophage migration inhibitory factor (MIF) activator, binds to MIF with Kd of 68.6 nM, regulates ARE-mediated gene expression. |
| PC-35091 |
JI051
Hes1 inhibitor
|
JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
| PC-35071 |
YC-001
Rod opsin antagonist
|
YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells, an inverse agonist and antagonist of rod opsin. |
| PC-63570 |
Siomycin A
FOXM1 inhibitor
|
Siomycin A (NSC 285116) is an antibiotic thiazole inhibitor of the oncogenic transcription factor FOXM1, down-regulates the transcriptional activity as well as the protein and mRNA abundance of FoxM1. |
| PC-63556 |
DS-2330
|
DS-2330 is a phosphorous lowering agent for treating hyperphosphatemia in chronic kidney disease.. |
| PC-63521 |
Peptide P60
FOXP3 inhibitor
|
Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3, exhibits functional inhibition of Treg in vitro and in vivo. |
| PC-63471 |
CD38 inhibitor 78c
CD38 inhibitor
|
CD38 inhibitor 78c (CD38 inhibitor 1, Compound 78c) is a potent, specific, reversible CD38 inhibitor with Ki of 14.5 nM for recombinant human CD38. |
| PC-63467 |
Syn-TEF1 intermediate 1
|
Syn-TEF1 intermediate 1 is a chemcal intermediate for Syn-TEF1 synthesis, which is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia. |
| PC-63457 |
CU239
RPE65 inhibitor
|
CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM. |
| PC-63456 |
ERGi-USU
RIOK2 inhibitor
|
ERGi-USU (NSC 139021) is a specific RIOK2 inhibitor, selectively inhibits ERG-positive cancer cell growth, directly binds (Kd=200 nM) and inhibits RIOK2 protein with IC50 of 220 nM (VCaP) and 360 nM (COLO320). |
