Catalog No.: PC-35481Not For Human Use, Lab Use Only.
JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures.
JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures.
JNJ-26489112 exhibits very weak inhibition of human CA-II (IC50=35 μM).
JNJ-26489112 inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects.
JNJ-26489112 shows limited seizure spread and elevated seizure threshold in preclinical animal models.
