| Cat. No. |
Product Name |
Information |
| PC-24661 |
Core Circadian Modulator
BMAL1 ligand
|
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions. |
| PC-24660 |
Lipoamide
CAS 940-69-2
|
Lipoamide (Alpha-lipoamide) is a neutral derivative of lipoic acid with antioxidant and organ-protective properties, specifically prevents cytoplasmic condensation of stress granule proteins including SRSF1 and SFPQ. |
| PC-24652 |
hCES2A inhibitor 9d
hCES2A inhibitor
|
hCES2A inhibitor 9d is a potent, selective and covalent human carboxylesterase 2A (hCES2A) inhibitor with IC50 of 0.12 nM and Ki of 0.43 nM. |
| PC-24651 |
LC-20W
hCES2A inhibitor
|
LC-20W is potent, reversible human carboxylesterase 2A (hCES2A) inhibitor with IC50 of 1.6 nM. |
| PC-24650 |
Cucurbitacin B
IGF2BP1 inhibitor
|
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product, an irreversible covalent inhibitor of IGF2BP1 and forms a covalent bond with cysteine 253 of the IGF2BP1 KH 1-2 domain (KD=66.8 nM). |
| PC-24649 |
IGF2BP1 inhibitor A11
IGF2BP1 inhibitor
|
IGF2BP1 inhibitor A11 is a specific small molecule insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) inhibitor, binds to IGF2BP) protein with KD of 2.88 nM. |
| PC-24648 |
DB2115 tertahydrochloride
PU.1 inhibitor
|
DB2115 tertahydrochloride is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM. |
| PC-24627 |
HSD17B13 inhibitor 32
HSD17B13 inhibitor
|
HSD17B13 inhibitor 32 is a highly potent, selective and liver-targeting HSD17B13 inhibitor with IC50 of 2.5 nM. |
| PC-24621 |
Fis1 inhibitor SP11
Fis1 inhibitor
|
SP11 is a potent inhibitor of activated Fis1 (mitochondrial fission protein 1), covalently binds specifically to Cys41 of activated Fis1, inhibits CPM fluorescence of Thr34Asp Fis1 with IC50 of 9.4 uM. |
| PC-24615 |
Digitonin
Detergent agent
|
Digitonin is a natural glycoside detergent glycoside obtained from Digitalis purpurea, can increase cell permeability by binding to cholesterol molecules and reduce tumor growth. |
| PC-24605 |
Concanavalin A
Liver injury inducer
|
Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin, can induce programmed cell death and acute liver injury. |
| PC-24596 |
SALL4 inhibitor SH6
SALL4 degrader
|
SALL4 inhibitor SH6 is a small molecule inhibitor of transcription factor SALL4 ZFC4 domain, selectively targets SALL4-expressing cancer cells (EC50=0.5 uM, SNU398 cells), degrades SALL4 protein through the CUL4A/CRBN pathway. |
