| Cat. No. |
Product Name |
Information |
| PC-23494 |
Ibetazol
Importin β inhibitor
|
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1. |
| PC-23451 |
PF-07328948
BDK inhibitor
|
PF-07328948 is the first potent, selective branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK) with in vitro IC50 of 15 nM, and cellular IC50 of 46 nM in human skeletal muscle BDK activity assay. |
| PC-23439 |
KB-151
Phagocytosis inhibitor
|
KB-151 is a small molecule phagocytosis inhibitor with IC50 of 2.7 uM in human PBMCs, shows no significant toxicity. |
| PC-23404 |
NAC1 inhibitor NIC3
NAC1 inhibitor
|
NAC1 inhibitor NIC3 is a specific small molecule inhibitor of oncogenic nucleus accumbens-associated protein-1 (NAC1), inhibits NAC1 homodimerization, leading to proteasomal NAC1 degradation. |
| PC-23325 |
Stomidazolone
Stomatal differentiation inhibitor
|
Stomidazolone is a doubly-sulfonylated imidazolone that inhibits stomatal differentiation, tightly binds to C-terminal ACT-Like (ACTL) domain of MUTE (Kd=8.9 uM) and perturbs the SCRM-MUTE heterodimerization. |
| PC-23304 |
PGMI-004A
PGAM1 inhibitor
|
PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM. |
| PC-23289 |
C071-0684
CHD1L inhibitor
|
C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells. |
| PC-23286 |
HKi2
HEG1-KRIT1 inhibitor
|
HKi2 (HEG1-KRIT1 inhibitor 2) is a specific small-molecule HEG1-KRIT1 inhibitor (IC50=3.5 uM) by competing orthosterically with HEG1 for binding to the KRIT1 FERM domain, elevates KLF4 and KLF2 gene expression and increases Akt phosphorylation. |
| PC-23260 |
Migalastat hydrochloride
α-Gal A inhibitor
|
Migalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of alpha-galactosidase A (α-Gal A) with IC50 of 0.04 uM (human α-Gal A). |
| PC-23229 |
SLCB050
DX2-p14/ARF inhibitor
|
SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression. |
| PC-23228 |
AM-001
EPAC1 inhibitor
|
AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity. |
| PC-23227 |
Tirasemtiv
Fast skeletal troponin activator
|
Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis. |
