| Cat. No. |
Product Name |
Information |
| PC-20506 |
SRC-3 inhibitor SI-10
SRC-3 inhibitor
|
SRC-3 inhibitor SI-10 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 8.5 nM, exhibits low hERG activity (IC50>10 uM). |
| PC-20505 |
MEISi-2
MEIS1 inhibitor
|
MEISi-2 (MEIS inhibitor 2) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity. |
| PC-20504 |
MEISi-1
MEIS1 inhibitor
|
MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity. |
| PC-20490 |
R805
gp130 modulator
|
R805 is a small molecule modulator of gp130 receptor pro-inflammatory signaling, targets a signaling tyrosine 814 (Y814) within gp130, modulates gp130 Y814 upstream of the SRC and MAPK circuit, elicits a protective effect on tissues after injury. |
| PC-20489 |
OSM-SMI-10B
Oncostatin M inhibitor
|
OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells. |
| PC-20459 |
Betulin
SREBP inhibitor
|
Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. |
| PC-20457 |
APC655
ATF6 activator
|
APC655 is a potent activator of protein folding and unfolded protein response (UPR) modulator, APC655 activates ATF6 pathway and chaperone expression. |
| PC-20454 |
Caf1 inhibitor 8j
Caf1 inhibitor
|
Caf1 inhibitor 8j is a potent, selective inhibitor of human poly(A)-selective ribonuclease Caf1 with IC50 of 0.59 uM, 40-fold selectivity over the related deadenylase PARN. |
| PC-20420 |
SC144
gp130 inhibitor
|
SC144 (SC-144) is the first-in-class orally active small-molecule gp130 inhibitor with a broad-spectrum anticancer activity. |
| PC-20404 |
ASP7967
RNA aptamer AC17-4 ligand
|
ASP7967 (ASP-7967) is a cell-permeable and low-toxic compound of RNA aptamer AC17-4 with SPR binding Kd of 12 nM, activates gene expression (>10-fold) in aptazyme-based riboswitches with EC50 of 2.3 uM. |
| PC-20400 |
DHAB
ADPR-cyclase inhibitor
|
DHAB is a potent, specific small molecule inhibitor of kidney ADPR-cyclase with IC50 of 2.5 nM, does not inhibit CD38, spleen, heart or brain ADPR-cyclase activity in vitro. |
| PC-20399 |
SAN4825
ADPR-cyclase inhibitor
|
SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM. |
