| Cat. No. |
Product Name |
Information |
| PC-49460 |
CLOCK inhibitor CLK8
CLOCK inhibitor
|
CLOCK inhibitor CLK8 is a CLOCK-binding small molecule disrupting the interaction between CLOCK and BMAL1, interferes with nuclear translocation of CLOCK both in vivo and in vitro. |
| PC-49409 |
ZHAWOC8697
SENP inhibitor
|
ZHAWOC8697 is a small molecule dual inhibitor of sentrin-specific protease SENP1 and SENP2 with IC50 of 8.6 and 2.3 uM, respectively, a valuable tool for the study of SUMOylation processes. |
| PC-49389 |
BAY-069
BCAT inhibitor
|
BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively. |
| PC-49386 |
S9-A13
SLC26A9 inhibitor
|
S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively. |
| PC-49381 |
Aldometanib
Aldolase inhibitor
|
Aldometanib (LXY-05-029) is a selective small molecule inhibitor of aldolase (ALDOA) with IC50 of 50 uM in in vitro enzymatic assays, Aldometanib (5 nM) is sufficient to activate AMPK inside cells. |
| PC-49359 |
PXS-4787
pan-LOX inhibitor
|
PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively. |
| PC-49358 |
PXS-6302
pan-LOX inhibitor
|
PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively. |
| PC-49319 |
SARM1 inhibitor NB-3
SARM1 inhibitor
|
SARM1 inhibitor NB-3 is a small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1, targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR). |
| PC-49293 |
JI130
Hes1 inhibitor
|
JI130 (JI 130) is a small molecule inhibitor of the cancer-associated transcription factor Hes1, targets prohibitin 2 (PHB2) and blocks Hes1-PHB2 interaction, JI130 inhibits MIA PaCa-2 cell growth with EC50 of 49 nM. |
| PC-49289 |
AZD4831
Myeloperoxidase inhibitor
|
AZD4831 (Mitiperstat, AZD-4831) is a potent, selective and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 1.5 nM, >450-fold vs thyroid peroxidase in vitro. |
| PC-49267 |
MLL1 CXXC inhibitor 1
MLL1 CXXC inhibitor
|
MLL1 CXXC inhibitor 1 is a small-molecule inhibitor of the MLL1 CXXC domain with IC50 of 7.1 uM, inhibits MLL CXXC domain-DNA binding activity. |
| PC-49246 |
DDX3X helicase 79
DDX3X inhibitor
|
DDX3X helicase 79 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 5 nM, shows antiviral activity against DENV-2 and WNV with EC50 of 1.6 and 2.3 uM, respectively. |
