| Cat. No. |
Product Name |
Information |
| PC-28461 |
LCL521 dihydrochloride
Acid ceramidase inhibitor
|
LCL521 dihydrochloride (1,3-di-DMG-B13) is a small molecular inhibitor of acid ceramidase (ACDase), a lysosomotropic inhibitor with anticancer activity. |
| PC-28458 |
Dafaglitapin
ALCAT1 inhibitor
|
Dafaglitapin (Juvenatin, Juve) is a potent and highly specific acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) inhibitor with IC50 of 3 nM. |
| PC-28422 |
PF-429242
S1P inhibitor
|
PF-429242 (PF429242) is a potent, selective, reversible and competitive inhibitor of proprotein convertase SREBP site 1 protease (S1P, Subtilisin kexin isozyme-1/SKI-1, MBTPS1) with IC50 of 170 nM. |
| PC-28412 |
F35-303
BEX4-XRCC5 inhibitor
|
F35-303 is a small molecule inhibitor of BEX4-XRCC5 interaction with IC50 of 2.39 uM in Huh6 cells, exhibits binding affinity for XRCC5 with SPR KD of 0.751 uM, suppresses NHEJ repair activity and reduces HB cells cell viability, inhibits cisplatin resistance. |
| PC-28396 |
α-Fluoromethylhistidine dihydrochloride
Histidine decarboxylase inhibitor
|
alpha-fluoromethylhistidine (α-FMH) is an orally active, irreversible histamine producing enzyme histidine decarboxylase (HDC) inhibitor with IC50 of 1-2 uM for soluble histidine decarboxylase preparations, inhibits histamine synthesis with IC50 of 0.2 uM in intact cell suspensions. |
| PC-28391 |
F-53B
CAS 73606-19-6
|
F-53B (6:2 Cl-PFAES) is a 6:2 chlorinated polyfluorinated ether sulfonate is an alternative to perfluorooctanesulfonate (PFOS) in electroplating industry, significantly inhibits the growth of zebrafish and induces reproductive toxicity. |
| PC-28366 |
MMS-350
Antifibrotic
|
MMS-350 is a DMSO analog and bis-oxetanyl sulfoxide that acts as a radiation protector and mitigator, reduces pulmonary fibrosis induced by different triggers, reduces levels of extracellular matrix proteins, the activation of fibroblasts, and the induction of pro-fibrotic factors. |
| PC-28360 |
XJB-5-131
Antioxidant
|
XJB-5-131 is hemigramicidin-TEMPO conjugate and mitochondria-targeted ROS and electron scavenger, reduces apoptosis and enhances cell survival in mouse embryonic cells in vitro, improves mitochondrial function. |
| PC-28349 |
Herbacetin
Ornithine decarboxylase inhibitor
|
Herbacetin is a naturally occurring flavonoid and potent, specific, allosteric ornithine decarboxylase (ODC) inhibitor, exhibits potent anticancer activity in colon cancer cell lines expressing high levels of ODC. |
| PC-28332 |
PANK-IN-3
PANK3 inhibitor
|
PANK-IN-3 is a high-affinity, selective inhibitor of PANK3 (Pantothenate kinase 3) with Ki of 4.2 nM, 104-fold selective over PanK1β. |
| PC-28331 |
PANK-IN-2
PANK inhibitor
|
PANK-IN-2 is a poten tinhibitor of Pantothenate kinase (PANK) with IC50 of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3 respectively in radiochemical enzyme assays. |
| PC-28330 |
PANK-IN-1
PANK3 inhibitor
|
PANK-IN-1 is a potent, pantothenate competitive inhibitor of Pantothenate kinase (PANK) with IC50 of 0.51 uM against PANK3. |
