| Cat. No. |
Product Name |
Information |
| PC-26617 |
BAY-771
BAY-069 control
|
BAY-771 is a negative control compound of dual BCAT1/2 inhibitor BAY-069. |
| PC-26616 |
BAY-252
BACT1/BACT2 inhibitor
|
BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50s of 2 μM and 2 μM, respectively. |
| PC-26585 |
FUBP1-IN-1
FUBP1 inhibitor
|
FUBP1-IN-1 is a small molecule inhibitor of transcriptional regulator FUSE binding protein 1 (FUBP1), inhibits the binding of FUBP1 to the FUSE sequence with IC50 of 11.0 uM, reduces cell expansion and induces of cell death in hepatocellular carcinoma cells. |
| PC-26574 |
Rnaseh2c-In1
Rnaseh2c inhibitor
|
Rnaseh2c-In1 is a specific small molecule inhibits of ribonuclease H2 subunit C (Rnaseh2c), significantly inhibits the proliferation of HCC via Cdk9 proliferation axis and CCL2/CCR2-mediated CD8+ Tex infiltration. |
| PC-26567 |
ELMO2 inhibitor C52
ELMO2 inhibitor
|
ELMO2 inhibitor C52 is a specific small-molecule Engulfment and cell motility 2 (ELMO2) inhibitor, binds to ELMO2 with a dissociation constant (KD) of 1.0 uM, effectively kills ELMO3-low lung cancer cells and EGFR inhibitor-resistant cells. |
| PC-26552 |
BTdCPU
HRI activator
|
BTdCPU is a potent activator of heme-regulated inhibitor (HRI) eIF2α kinase that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone-resistant cancer cells. |
| PC-26503 |
Z1149421873
NAP1L1 inhibitor
|
Z1149421873 (Z11) is a small-molecule inhibitor of NAP1L1 with SPR Kd value of 7.86 nM, inhibits its protein expression in vitro and exerts anti-fibrotic effects in PMCFs. |
| PC-26502 |
SARM1 inhibitor 19
SARM1 inhibitor
|
SARM1 inhibitor 19 is a potent, selective and orally bioavailable SARM1 inhibitor with pIC50 of 7.1 (hSARM1), protect primary rat and mouse DRGs treated with vincristine with EC50 of 55 nM and 113 nM respectively. |
| PC-26495 |
S-Nitroso-N-acetyl-DL-penicillamine
NO donor
|
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a synthetic NO donor that releases NO under physiological conditions, acts as a stable inhibitor of platelet aggregation. |
| PC-26455 |
Z1692774161
ROBO2 binder
|
Z1692774161 is a small molecule ligand of Roundabout homolog 2 (ROBO2), bind ROBO2 in a reproducible concentration-dependent manner with KD of 25.8 uM. |
| PC-26454 |
SMEI inhibitor 20e
SMEI inhibitor
|
SMEI inhibitor 20e is a small molecule inhibitor targeting SCN1A-associated severe myoclonic epilepsy of infancy (SMEI), shows potent antiseizure efficacy in zebrafish behavioral assays and significantly reduces locomotion-related seizure parameters, elevates 5-HT levels via TPH2 upregulation. |
| PC-26450 |
ACSS2-IN-1
ACSS2 inhibitor
|
ACSS2-IN-1 is a higly potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.01 nM to <1 nM. |
