| Cat. No. |
Product Name |
Information |
| PC-42293 |
EC330
LIF inhibitor
|
EC330 (EC-330, EC 330) is a first-in-class, orally bioavailable LIF (leukemia inhibitory factor, LIFR) inhibitor. |
| PC-45088 |
SP-420
Iron chelating agent
|
Petadeferitrin (SP-420) is a desferrithiocin analogue and iron chelating agent that has iron-clearing efficiency with ICE value of 26.7, SP-420 is more potent than desferrithiocin. |
| PC-45513 |
HQ-415
Metal chelator, TDP-43 modulator
|
HQ-415 is a derivative of 8-hydroxyquinoline that has selectivity for rescuing the distinct toxicities caused by the expression of TDP-43 with EC50 of 15 uM, α-synuclein or polyglutamine proteins. |
| PC-45271 |
Pramiracetam
Cognitive activator
|
Pramiracetam (CI-879) is a central nervous system stimulant and nootropic agent and PREP (prolyl endopeptidase) inhibitor, shows cognition-restoring and neuroprotective properties. |
| PC-42072 |
BAPTA
Mg2+ chelator
|
BAPTA is a cell-permeant, calcium-specific chelator with high selectivity over Mg2+. |
| PC-45623 |
GW4869
nSMase inhibitor
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-28707 |
CINS-1
RIOK1 inhibitor
|
CINS-1 is a potent, specific RIO Kinase 1 (RIOK1) inhibitor with high binding affinity (ITC Kd=97 nM, AfRIOK1), binds to human RIOK1 with a Kd of 176 nM, exhibits antiproliferative activity against CRC cell lines HCT116 with IC50 of 7.81 uM. |
| PC-28703 |
CDD-3155
STK33 inhibitor
|
CDD-3155 is a potent, selective Serine/threonine kinase 33 (STK33) inhibitor with IC50 of 1.83 uM and Kd of 0.863 nM, 446-fold selective over CLK4 (based on Kd value). |
| PC-28702 |
CDD-3094
STK33 inhibitor
|
CDD-3094 is a potent, selective Serine/threonine kinase 33 (STK33) inhibitor with IC50 of 56.3 nM and Kd of 0.087 nM, 21-fold selective over CLK4 (based on Kd value). |
| PC-28697 |
ATF4/CHOP inhibitor T-22
ATF4/CHOP inhibitor
|
ATF4/CHOP inhibitor T-22 is a potent, specific CHOP/ATF4 inhibitor, inhibits CHOP expresion with IC50 of 1.41 uM in CHOP-Luc assay under ER stress conditions, significantly inhibits ATF4 mRNA expression. |
