| Cat. No. |
Product Name |
Information |
| PC-42072 |
BAPTA
Mg2+ chelator
|
BAPTA is a cell-permeant, calcium-specific chelator with high selectivity over Mg2+. |
| PC-45623 |
GW4869
nSMase inhibitor
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-28670 |
Oxybipin-1
OSBP inhibitor
|
Oxybipin-1 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 77 nM, impair retrograde trafficking. |
| PC-28626 |
TRiCi
TCP1 inhibitor
|
TRiC inhibitor (TRiCi) is specific small molecule inhibitor of TRiC subunit TCP1, inhibits archaeal TCP1 activity in vitro, inducing decrease in CSA levels while not affecting TCP1 levels. |
| PC-28614 |
Iopanoic acid
Deiodinase inhibitor
|
Iopanoic acid (IOP) is a potent inhibitor of type I and type II 5'-deiodinase (DIO1 and DIO2), produces rapid, reversible suppression of peripheral thyroxine (T4) to T3 conversion, alongside comparative rescue strategies including Lugol's iodine, perchlorate, lithium, cholestyramine. |
| PC-28607 |
Retinylamine
Visual cycle inhibitor
|
Retinylamine (Ret-NH2) is a potent inhibitor of the rod visual cycle, inhibits 11-cis-retinol production in isomerase assay with IC50 of 500 nM, potently and selectively inhibits the isomerization step of the retinoid cycle in vitro and in vivo. |
| PC-28604 |
Z247611722
Serine palmitoyltransferase inhibitor, Antifungal
|
Z247611722 is a novel antifungal, inhibitor of sphingolipid biosynthesis and serine palmitoyltransferase (SPT) displays fungicidal activity against multiple Candida species (C. albicans, MIC=1.56 uM) and fluconazole-resistant isolates. |
| PC-28601 |
MO2455
CAS 2097009-11-3
|
MO2455 is a synthesized imatinib-derived compound that exert potent cytotoxic effects on leukemia cells with IC50 of 0.83 μM, 0.43 μM and 0.57 μM in U937, THP-1 and CCRF-CEM cells, promotes leukemic cell death by activating the intrinsic apoptotic pathway. |
| PC-28598 |
N-Acetylcysteine amide
Antioxidant
|
N-acetylcysteine amide (NACA) is a blood-brain-barrier permeable antioxidant and glutamate-modulating compound, reduces ROS production and shows neuroprotective activity. |
| PC-28595 |
MR-409
GHRH agonist
|
MR-409 (MR 409, MR409) is a synthetic GHRH analogue and growth hormone-releasing hormone receptor (GHRHR) agonist with binding IC50 of 1.01 nM in membrane GHRHR of human pituitary cells, exhibits high growth hormone-releasing potency. |
