| Cat. No. |
Product Name |
Information |
| PC-47087 |
IL-17A PPIm 23
IL-17A modulator
|
IL-17A PPIm 23 is a potent, orally bioavailable, small-molecule protein-protein interaction modulator (PPIm) of IL-17A, shows potential treatment of psoriasis and other inflammatory diseases. |
| PC-47085 |
RG3039
DcpS inhibitor
|
RG3039 (PF-06687859) is a potent, orally bioavailable and brain-penetrant inhibitor of the ribonucleic acid scavenger enzyme DcpS with IC50 of 3.4 nM. |
| PC-47083 |
TH10785
OGG1 activator
|
TH10785 is a small-molecule activator of 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), increases the enzyme activity 10-fold, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage in cells. |
| PC-47075 |
GBT1118
Hemoglobin modifier
|
GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain. |
| PC-47074 |
RPI-194
Troponin activator
|
RPI-194 is a novel troponin activator that binds to cardiac/slow skeletal muscle troponin, binds to cardiac troponin with KD of 24 uM, stabilizing the activated complex between troponin C and the switch region of troponin I. |
| PC-47073 |
cjoc42
Gankyrin inhibitor
|
cjoc42 is a specific small molecule that is capable of binding to gankyrin (ITC Kd=580 nM), inhibit gankyrin activity in a dose-dependent manner. |
| PC-47071 |
Carmofur
ASAH1 inhibitor
|
Carmofur (HCFU) is a pyrimidine analogue with antineoplastic activity, Carmofur is a highly potent acid ceramidase (ASAH1) inhibitor with IC50 of 29 nM (rat recombinant ASAH1). |
| PC-47066 |
UNC7938
Endosomolytic compound
|
UNC7938 (UNC10217938 ) is a small molecule that enhance the escape of oligonucleotides from intracellular membrane compartments, enhance the delivery of oligonucleotides. |
| PC-47060 |
GNF-9228
β-cell proliferation activator
|
GNF-9228 is a small molecule that stimulates human β-cell proliferation, selectively activates human β-cell relative to α- or δ-cell proliferation. |
| PC-47057 |
MK-0159
CD38 inhibitor
|
MK-0159 is a highly potent, orally bioavailable CD38 enzymatic inhibitor with IC50 of 3 nM (murine CD38) in in vitro assays. |
| PC-47056 |
ZY-444
Pyruvate carboxylase inhibitor
|
ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway. |
| PC-47049 |
IPHBA
IL-31 inhibitor
|
IPHBA is a small-molecule inhibitor that suppresses EPAS1-driven IL-31 induction, selectively inhibits TCR-mediated IL-31 induction in murine CD4+ T cells with IC50 of 10.6 uM. |
