| Cat. No. |
Product Name |
Information |
| PC-28703 |
CDD-3155
STK33 inhibitor
|
CDD-3155 is a potent, selective Serine/threonine kinase 33 (STK33) inhibitor with IC50 of 1.83 uM and Kd of 0.863 nM, 446-fold selective over CLK4 (based on Kd value). |
| PC-28697 |
ATF4/CHOP inhibitor T-22
ATF4/CHOP inhibitor
|
ATF4/CHOP inhibitor T-22 is a potent, specific CHOP/ATF4 inhibitor, inhibits CHOP expresion with IC50 of 1.41 uM in CHOP-Luc assay under ER stress conditions, significantly inhibits ATF4 mRNA expression. |
| PC-28682 |
GCN2 activator-1
GCN2 activator
|
GCN2 activator-1 (Compound 20) is a GCN1-independent small molecule GCN2 activator, binds within the ATP-pocket of GCN2, inhibits PKR (EIF2AK2) in vitro with IC50 of 3.75 uM. |
| PC-28675 |
OICR18704
ClpP inhibitor
|
OICR18704 is a potent, specific, allosteric inhibitor of human mitochondrial ClpP protease with IC50 of 13.7 nM and EC50 of 0.3 uM in cellular thermal shift assays (CETSA). |
| PC-28670 |
Oxybipin-1
OSBP inhibitor
|
Oxybipin-1 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 77 nM, impair retrograde trafficking. |
| PC-28626 |
TRiCi
TCP1 inhibitor
|
TRiC inhibitor (TRiCi) is specific small molecule inhibitor of TRiC subunit TCP1, inhibits archaeal TCP1 activity in vitro, inducing decrease in CSA levels while not affecting TCP1 levels. |
| PC-28614 |
Iopanoic acid
Deiodinase inhibitor
|
Iopanoic acid (IOP) is a potent inhibitor of type I and type II 5'-deiodinase (DIO1 and DIO2), produces rapid, reversible suppression of peripheral thyroxine (T4) to T3 conversion, alongside comparative rescue strategies including Lugol's iodine, perchlorate, lithium, cholestyramine. |
| PC-28607 |
Retinylamine
Visual cycle inhibitor
|
Retinylamine (Ret-NH2) is a potent inhibitor of the rod visual cycle, inhibits 11-cis-retinol production in isomerase assay with IC50 of 500 nM, potently and selectively inhibits the isomerization step of the retinoid cycle in vitro and in vivo. |
| PC-28601 |
MO2455
CAS 2097009-11-3
|
MO2455 is a synthesized imatinib-derived compound that exert potent cytotoxic effects on leukemia cells with IC50 of 0.83 μM, 0.43 μM and 0.57 μM in U937, THP-1 and CCRF-CEM cells, promotes leukemic cell death by activating the intrinsic apoptotic pathway. |
| PC-28598 |
N-Acetylcysteine amide
Antioxidant
|
N-acetylcysteine amide (NACA) is a blood-brain-barrier permeable antioxidant and glutamate-modulating compound, reduces ROS production and shows neuroprotective activity. |
| PC-28595 |
MR-409
GHRH agonist
|
MR-409 (MR 409, MR409) is a synthetic GHRH analogue and growth hormone-releasing hormone receptor (GHRHR) agonist with binding IC50 of 1.01 nM in membrane GHRHR of human pituitary cells, exhibits high growth hormone-releasing potency. |
| PC-28594 |
MP-002
FKBP12 ligand
|
MP-002 (AHK2) is a triazole-based FKBP12 ligand, competes with rapamycin for the FKBP12 binding pocket, stabilizing the FKBP12/RyR interaction, rescues multiple premature aging phenotypes in dyotonic dystrophy type 1 (DM1) models. |
