| Cat. No. |
Product Name |
Information |
| PC-72545 |
SMIP004-7
complex I inhibitor
|
SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I). |
| PC-72542 |
Compound 2F52
Vaccine adjuvant
|
Compound 2F52 is a synthetic small-molecule vaccine adjuvant for influenza virus infection, activator of innate immunity via mitochondrial stress pathways, acts independently of known TLRs and PRRs. |
| PC-72538 |
DHODH inhibitor GSK983
DHODH inhibitor
|
GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM. |
| PC-72537 |
AL-GDa62
SUMOylation inhibitor
|
AL-GDa62 is a specific inhibitor of TCOF1, ARPC5, and UBC9, inhibits SUMOylation at low micromolar concentrations. |
| PC-72531 |
HLM006474
E2F inhibitor
|
HLM006474 is a selective small-molecule E2F inhibitor, inhibits E2F4 DNA-binding with IC50 of 29.8 uM in A549 cells. |
| PC-72525 |
X5050
REST inhibitor
|
X5050 (X-5050) is a small molecule that inhibits REST silencing in a RE1-dependent manner, targeted REST degradation. |
| PC-72523 |
Omilancor
LANCL2 agonist
|
Omilancor (BT-11) is a locally-acting, first-in-class, small molecule that selectively activates the Lanthionine Synthetase C-like 2 (LANCL2) pathway. |
| PC-72520 |
BAY-179
Complex I inhibitor
|
BAY-179 (BAY179) is a potent, selective, and species cross-reactive Complex I inhibitor with IC50 of 79 nM. |
| PC-72515 |
ELOVL1-IN-22
ELOVL1 inhibitor
|
ELOVL1-IN-22 is a potent, selective, CNS-penetran inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme, reduces C26:0 VLCFA synthesis in HEK293 with EC50 of 0.4 nM. |
| PC-72504 |
ARSA-IN-1r
ARSA inhibitor
|
ARSA-IN-1r (ARSAi) is the first reversible inhibitor of human Arylsulfatase A (ARSA) with SPR KD of 21 uM and IC50 of 13.2 uM. |
| PC-72501 |
JH-RE-06
REV1-REV7 inhibitor
|
JH-RE-06 is a potent REV1-REV7 interface inhibitor (IC50=0.78 uM, Kd=0.42 uM) that disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ, induces REV1 dimerization and blocks POLζ recruitment. |
| PC-72498 |
Macrocyclic peptide D4-2
CD47-SIRPα inhibitor
|
Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM). |
