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Cat. No. Product Name Information
PC-72440

AQX-435

SHIP1 activator

AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation.
PC-72433

GRP-60367

RABV entry inhibitor

GRP-60367 (GRP60367) is a first-in-class, potent and specific, direct-acting rabies virus (RABV) inhibitor with EC50 of 2-52 nM on different host cell lines, inhibits entry of a subset of RABV strains.
PC-72408

SACLAC

Acid ceramidase inhibitor

SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.
PC-72399

Pannexin-1 inhibitor 15b

Pannexin-1 inhibitor

Panx-1 blocker 15b is a large-pore channel pannexin 1 (Panx1) inhibitor with IC50 of 0.8 uM.
PC-72398

NCATS-SM4487

GALK1 inhibitor

NCATS-SM4487 is a potent, small molecule inhibitor galactokinase (GALK1) with IC50 of 50 nM (hGALK1).
PC-72391

cis-Epoxysuccinic acid

SUCNR1 (GPR91) agonist

cis-Epoxysuccinic acid (cSE) is a synthetic non-metabolite GPR91 agonist with EC50 of 2.7 uM (cAMP levels reducion).
PC-72383

SRI-37330

TXNIP inhibitor

SRI-37330 (SRI 37330) is an orally available small molecule that regulates TXNIP expression, inhibits endogenous TXNIP mRNA expression (IC50=0.64 uM, INS-1 cells qRT-PCR assays).
PC-72381

HKB99

PGAM1 inhibitor

HKB99 (PGAM1 allosteric inhibitor HKB99) is a novel potent, cellularly active PGAM1 (Phosphoglycerate mutase 1) allosteric inhibitor, HKB99 is noncompetitive with the substrate 3-PG with IC50 of 0.85 uM in in vitro enzyme assays.
PC-72380

SUCNR1 inhibitor 20

SUCNR1 (GPR91) antagonist

SUCNR1 inhibitor 20 is a potent, selective inhibitor (antagonist) of GPCR SUCNR1 (succinate receptor 1/GPR91) with IC50 of 88 nM.
PC-72374

NF-56-EJ40

SUCNR1 (GPR91) antagonist

NF-56-EJ40 is a highly potent, human-selective antagonist of SUCNR1 (GPR91) with IC50 of 25 nM and Ki of 33 nM.
PC-72370

Ophiobolin A

Calmodulin inhibitor

Ophiobolin A (OphA) is a potent, covalent CaM inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor.
PC-72352

Calmirasone1

Calmodulin inhibitor

Calmirasone1 (Calmirasone 1) is a novel and potent covalent calmodulin (CaM) inhibitor with Kd of 0.87 uM.

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