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SOCS1 inhibitor 20

Chemical Structure : SOCS1 inhibitor 20

CAS No.:

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SOCS1 inhibitor 20 (MpYTTVAD)

Catalog No.: PC-72813Not For Human Use, Lab Use Only.

SOCS1 inhibitor 20 is a specific, cell-permeable phosphotyrosine peptide that target the SH2 domain of SOCS1 (Suppressor of cytokine signaling 1) with IC50 of 20 nM (hSOCS1)

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SOCS1 inhibitor 20 (MpYTTVAD) is a specific, cell-permeable phosphotyrosine peptide that target the SH2 domain of SOCS1 (Suppressor of cytokine signaling 1) with IC50 of 20 nM (hSOCS1).
    SOCS1 inhibitor 20 dispalys >100-fold selectivity against the closely related SOCS family proteins CIS, SOCS2/3.
    SOCS1 inhibitor 20 stabilize SOCS1 in a thermal shift assay using cell lysates and inhibited SOCS1-mediated ubiquitination of a target substrate in a biochemical assay.

    Physicochemical Properties

    M.Wt 878.89
    Formula C34H55N8O15PS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Month
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Met-pTyr-Thr-Thr-Val-Ala-Asp

    References

    1. Hao Chen, et al. ACS Chem Biol. 2022 Jan 6. doi: 10.1021/acschembio.1c00884.

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