| Cat. No. |
Product Name |
Information |
| PC-27195 |
MIPO
NEK9 inhibitor
|
MIPO is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 7.72 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.8 uM and 19.7 uM. |
| PC-27194 |
ICCB280
C/EBPalpha agonist
|
ICCB280 is a specific small molecule C/EBPalpha (C/EBPα) agonist, induces myeloid differentiation of leukemia cell lines by increasing expression of C/EBPα and C/EBPε, and decreasing expression of c-Myc. |
| PC-27187 |
LRI-305
LIF antagonist
|
LRI-305 (LRI305) is a selective antagonist of Leukemia Inhibitory Factor (LIF) receptor (LIFR), effectively inhibits LIF/LIFR interaction with with IC50 of 0.86 uM in Alpha Screen assays. |
| PC-27168 |
Maresin 1
Macrophage proresolving mediator
|
Maresin-1 (Maresin 1, MaR1) is a potent anti-inflammatory and proresolving mediator biosynthesized by macrophages (MΦs), enhances phagocytosis. |
| PC-27147 |
Zinc protoporphyrin IX
HO-1 inhibitor
|
ZnPP-9 (Zinc protoporphyrin IX, ZnPP-9, Zinc protoporphyrin-9) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor, regulates expression of HO-1 at the transcriptional level, demonstrates potent antitumor effects. |
| PC-27141 |
STK33-IN-1
STK33 inhibitor
|
STK33-IN-1 is a highly potent serine/threonine kinase STK33 inhibitor with IC50 of 7 nM, inhibitsa number of other kinases in addition to STK33. |
| PC-27139 |
EYA2 degrader EC21
EYA2 degrader
|
EYA2 degrader EC21 is a bifunctional small molecule EYA2 degrader via CDK6 recruitment, enhances the interaction between CDK6 and EYA2, thereby promoting EYA2 degradation, disrupts DNA damage repair pathways and significantly suppresses breast cancer cell proliferation. |
| PC-27130 |
VU0619195
Ordered membrane domains inhibitor
|
VU0619195 is a small molecule disruptor of ordered membrane domains in cells, destabilize raft formation and decrease protein partitioning reduced the raft affinities of both PMP22 and MAL with EC50 of 1.62 uM and 1.37 uM. |
| PC-27125 |
CTL4 inhibitor DT-13
CTL4 inhibitor
|
CTL4 inhibitor DT-13 is a potent small molecule choline transporter-like protein 4 (CTL4) inhibitor with IC50 of 12.47 uM, directly binds to CTL4 with MST Kd of 0.64 uM, inhibits CTL4-mediated choline uptake. |
| PC-27098 |
Creatine transporter 1-IN-1
CT1/SLC6A8 inhibitor
|
Creatine transporter 1-IN-1 is a small molecule creatine transporter 1 (CT1, SLC6A8), inhibits substrate uptake by CT1 in CT1 expressing HEK293 cells with IC50 of 55 uM. |
| PC-27082 |
OICR-403184
PKR inhibitor
|
OICR-403184 is a potent, selective inhibitor of RNA-dependent protein kinase PKR with IC50 of 263 nM, shows minimal activity against related eIF2α kinases and BRAF. |
| PC-27060 |
CIB-Q22
Pyruvate carboxylase inhibitor
|
CIB-Q22 is a potent pyruvate carboxylase (PC) inhibitor with IC50 of 1.74 nM, suppresses HCC cell viability (IC50=25.18 nM). |
