| Cat. No. |
Product Name |
Information |
| PC-26085 |
IDB-001
Translation inhibitor
|
IDB-001 is a small molecule, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation. |
| PC-26079 |
TREM2 agonist S9
TREM2 agonist
|
TREM2 agonist S9 is a potent, small molecule Triggering receptor expressed on myeloid cells-2 (TREM2) agonist with MST binding KD of 0.95 uM. |
| PC-26078 |
HCY-NBD
GSTM2 stablizer
|
HCY-NBD is a small molecule stabilizer of Glutathione S-transferase Mu 2 (GSTM2), promotes sulfenylation at Cys174 of GSTM2 and inhibits its K48-linked ubiquitination at this residue, stabilizes GSTM2 protein levels. |
| PC-26063 |
Berberrubine chloride
TDP-43 aggregation inhibitor
|
Berberrubine chloride is an orally active metabolite of berberine, alleviates mucosal lesions and inflammation in mouse colitis models, inhibits TDP-43 aggregation and shows anti-inflammatory, anti-tumor, and antiviral activities. |
| PC-26054 |
AGS8-IN-1
AGS8 inhibitor
|
AGS8-IN-1 is a small molecule inhibitor of activator of G-protein signaling 8 (AGS8), effectively inhibits the formation of the AGS8-Gβγ complex, attenuates VEGF-induced phosphorylation of signaling molecules and inhibits tube formation and migration of HUVECs. |
| PC-25998 |
TMA Lyase inhibitor 7
TMA Lyase inhibitor
|
TMA Lyase inhibitor 7 is a highly potent, selective Trimethylamine (TMA) Lyase inhibitor with IC50 of 0.4 nM, significant reduces circulating trimethylamine oxide (TMAO) levels in vivo. |
| PC-25965 |
ML194
GPR35 antagonist
|
ML194 is a potent, selective GPR35 antagonist with IC50 of 160 nM, has >57-fold selectivity over GPR55 orphan receptor. |
| PC-25962 |
CVN527
GPR6 inverse agonist
|
CVN527 is a potent and selective, brain penetrant GPR6 inverse agonist, fully inhibits GPR6 with EC50 of 39.5 nM and 34 nM for mouse and human GPR6 in functional GPR6 cAMP HTRF cell -based assays. |
| PC-25942 |
TREM-1 inhibitory peptide GF9
TREM-1 inhibitor
|
TREM-1 inhibitory peptide GF9 is a peptide inhibitor of Triggering receptor expressed on myeloid cells 1 (TREM-1), significantly inhibits pancreatic cancer progression. |
| PC-25930 |
GPR81 agonist 1
GPR81 agonist, HCAR1 agonist
|
GPR81 agonist 1 is a potent and highly selective GPR81 agonist with EC50 of 58 nM and 50 nM for human and mouse GPR81 respectively, also is an agonist-positive allosteric modulator (Ago-PAM) for HCAR1. |
| PC-25903 |
2-Bromopalmitate
Palmitoylation inhibitor
|
2-Bromopalmitate (2-Bromohexadecanoic acid, 2-Bromopalmitic acid) is a broad-spectrum palmitoylation inhibitor, inhibits ZDHHC11-mediated palmitoylation, inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis. |
| PC-25886 |
Them1 inhibitor Compound U11
Them1 inhibitor
|
Them1 inhibitor Compound U11 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 3.63 uM, selectively inhibits Them1 by binding the START domain (Kd=0.67 uM). |
