Chemical Structure : Gαi2 inhibitor GT-14
CAS No.:
2794979-74-9
Gαi2 inhibitor GT-14
Catalog No.: PC-26189Not For Human Use, Lab Use Only.
GT-14 is a first-generation small molecule inhibitor of Gαi2 protein, inhibits cancer cell migration and prevents Gαi2 activation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GT-14 is a first-generation small molecule inhibitor of Gαi2 protein, inhibits cancer cell migration and prevents Gαi2 activation.
GT-14 (10 uM) significantly inhibited the migratory behavior of the PC3 and DU145 prostate cancer cell lines.
GT-14 (10 uM) blocks the activation of Gαi2 in oxytocin-stimulated prostate cancer PC3 cells, and inhibits the migratory capability of DU145 cells overexpressing the constitutively active form of Gαi2, under basal and EGF-stimulated conditions.
GT-14 blocks the activation of Gαi2 in oxytocin-stimulated prostate cancer PC3 cells.
GT-14 induces the phosphorylation of CREB protein, downstream effector of cAMP production and negatively regulates the migration of the renal and ovarian cancer cell lines.
Physicochemical Properties
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M.Wt
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264.33
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Formula
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C17H16N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-4-((1-(1-methyl-1H-indol-2-yl) ethylidene)amino)phenol
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References
1. Sarkar M, et al. AAPS J. 2025 Dec 1;28(1):23.
2. Sarkar M, et al. J Pharm Biomed Anal. 2024 Aug 1;245:116183.
3. Caggia S, et al. Cancers (Basel). 2020;12(6).
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