| Cat. No. |
Product Name |
Information |
| PC-27087 |
S428-1145
PUS7 inhibitor
|
S428-1145 is a small molecule inhibitor targeting pseudouridine synthase 7 (PUS7), has anti-proliferative IC50 of 20 µM in MIA PaCa-2 cells and 20.68 µM in PANC-1 cells, respectively, significantly inhibits tumour growth. |
| PC-27049 |
SB-583355
GPR132 antagonist
|
SB-583355 is a potent, peptidomimetic inhibitor of GPR132 (G2A), inhibits agonist-induced hGPR132aPL association with β-arrestin with pIC50 of 7.0. |
| PC-27047 |
SKF-95667
GPR132 agonist
|
SKF-95667 is a potent, selective agonist of G-protein-coupled receptor GPR132 (G2A) with pEC50 of 6.6 and 5.8 in yeast and β-arrestin assays (human GPR132a). |
| PC-27046 |
GSK1820795A
GPR132 antagonist
|
GSK1820795A is a potent, specific antagonist of G-protein-coupled receptor GPR132 (G2A), blocks agonist-induced association of hGPR132 with β-arrestin with pIC50 of 7.8, also is a dual angiotensin AT1 antagonist and PPARγ modulator. |
| PC-26951 |
AGPS-IN-1
AGPS inhibitor
|
AGPS-IN-1 (AGPS inhibitor 2i) is a small molecule inhibitor of alkylglyceronephosphate synthase (AGPS), decreases ether lipids, cell migration and survival, specifically impairs EMT through E-cadherine, Snail, Mmp2 modulation. |
| PC-26936 |
NCGC00685960
NNMT inhibitor
|
NCGC00685960 is a highly potent, specific Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 of <10 nM, increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts, has potent antitumor activity. |
| PC-26922 |
GPR52 agonist R-185
GPR52 agonist
|
GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice. |
| PC-26919 |
SSKP-0076
Ybx1 inhibitor
|
SSKP-0076 is a small molecule inhibitor of Y-box binding protein 1 (Ybx1), inhibits invasion and migration of LM8 osteosarcoma cells. |
| PC-26882 |
SIH-002
ZMIZ1 inhibitor
|
SIH-002 is a specific small-molecule inhibitor of ZMIZ1 (Zinc finger MIZ domain-containing protein 1) with SPR KD of 0.16 uM. |
| PC-26881 |
SIH-001
ZMIZ1 inhibitor
|
SIH-001 is a specific small-molecule inhibitor of ZMIZ1 (Zinc finger MIZ domain-containing protein 1) with SPR KD of 0.498 uM. |
| PC-26874 |
A-3190
CD38 inhibitor
|
A-3190 (A3190) is a potent, selective, brain-penetrant CD38 inhibitor with IC50 of 7.2 nM and 1.2 nM for human and mouse CD38 respectively. |
| PC-26872 |
CPN-219
NMUR2 agonist
|
CPN-219 is a potent, selective, next-generation hexapeptidic neuromedin U receptor type 2 (NMUR2) agonist with EC50 value of 2.2 nM. |
