| Cat. No. |
Product Name |
Information |
| PC-26778 |
Ligustilide
MEOX1 inhibitor
|
Ligustilide is a potential inhibitor of mesenchyme homeobox 1 (MEOX1), exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects, exerts significant antifibrotic effects through inhibition of MEOX1 and the downstream of the Hippo signalling pathway. |
| PC-26769 |
MEDS700
DHODH inhibitor
|
MEDS700 is a potent, selective, blood-brain barrier permeable hDHODH inhibitor with IC50 of 1.5 nM. |
| PC-26744 |
TTBK1-IN-2
TTBK1 inhibitor
|
TTBK1-IN-2 (Compound 29) is a potent, brain penetrant Tau-Tubulin kinase (TTBK1) inhibitor with IC50 of 0.24 uM, reduces TDP-43 phosphorylation both in vitro and in vivo. |
| PC-26724 |
MS351
CBX7 inhibitor
|
MS351 (MS-351) is a specific small molecule antagonist of chromobox 7 (CBX7) chromodomain (CBX7ChD) with Kd of approximately 500 uM by NMR titration, disrupts H3K27me3-mediated CBX7 binding to target genes in chromatin. |
| PC-26717 |
HF-125
TRIB2 inhibitor
|
HF-125 is a potent, selective small molecule inhibitor of Tribbles 2 (TRIB2), directly binds to destabilize and degrade TRIB2 proteins involving proteasomes and is effective both in vitro and in vivo. |
| PC-26684 |
LMT328
Sulfiredoxin inhibitor
|
LMT328 (LMT-328) is a potent inhibitor of sulfiredoxin (Srx) with IC50 of 6.7 uM. |
| PC-26649 |
mtCI modulator C273
Mitochondrial complex I inhibitor/modulator
|
mtCI modulator C273 is a selective, brain-penetrant, orally bioavailable small molecule modulator/ weak inhibitor of mitochondrial complex I (mtCI) with IC50 of 201.5 uM, protects against Aβ toxicity through mtCI modulation. |
| PC-26615 |
ERG245
BCAT1 inhibitor
|
ERG245 is a potent, selective BCAT1 inhibitor with IC50 of 0.5 nM for recombinant human BCAT1 (rhBCAT1), >2000-fold selectivity for BCAT1 over BCAT2. |
| PC-26613 |
ERG240
BCAT1 inhibitor
|
ERG240 (ERG-240) is a potent, selective, orally active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor, inhibits recombinant BCAT1 with an IC50 of 0.1-1 nM, with no inhibition on BCAT2. |
| PC-26553 |
ZNF281 inhibitor ZIM
ZNF281 inhibitor
|
ZNF281 inhibitor ZIM (ZNF281 Interfering Molecule) is a specific small molecule inhibitor of transcription factor ZNF281, prevents anthracycline-mediated cardiotoxicity (AIC), enhances lung tumor regression, and prevents lung metastasis in a metastatic melanoma model. |
| PC-26548 |
SOD1 stabilizer C7
SOD1 binder
|
SOD1 stabilizer C7 is a SOD1-stabilizing small molecule preferentially bound the native-like conformation of SOD1, inhibits irreversible apo-SOD1 misfolding in vitro. |
| PC-26506 |
CCF0054500
OR2L13 agonist
|
CCF0054500 is a specific small molecule agonist of orphan GPCR OR2L13, inhibits platelet aggregation in platelet-rich plasma (PRP) with EC50 of 14 uM. |
