| Cat. No. |
Product Name |
Information |
| PC-47087 |
IL-17A PPIm 23
IL-17A modulator
|
IL-17A PPIm 23 is a potent, orally bioavailable, small-molecule protein-protein interaction modulator (PPIm) of IL-17A, shows potential treatment of psoriasis and other inflammatory diseases. |
| PC-47085 |
RG3039
DcpS inhibitor
|
RG3039 (PF-06687859) is a potent, orally bioavailable and brain-penetrant inhibitor of the ribonucleic acid scavenger enzyme DcpS with IC50 of 3.4 nM. |
| PC-47083 |
TH10785
OGG1 activator
|
TH10785 is a small-molecule activator of 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), increases the enzyme activity 10-fold, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage in cells. |
| PC-47074 |
RPI-194
Troponin activator
|
RPI-194 is a novel troponin activator that binds to cardiac/slow skeletal muscle troponin, binds to cardiac troponin with KD of 24 uM, stabilizing the activated complex between troponin C and the switch region of troponin I. |
| PC-47073 |
cjoc42
Gankyrin inhibitor
|
cjoc42 is a specific small molecule that is capable of binding to gankyrin (ITC Kd=580 nM), inhibit gankyrin activity in a dose-dependent manner. |
| PC-47071 |
Carmofur
ASAH1 inhibitor
|
Carmofur (HCFU) is a pyrimidine analogue with antineoplastic activity, Carmofur is a highly potent acid ceramidase (ASAH1) inhibitor with IC50 of 29 nM (rat recombinant ASAH1). |
| PC-47057 |
MK-0159
CD38 inhibitor
|
MK-0159 is a highly potent, orally bioavailable CD38 enzymatic inhibitor with IC50 of 3 nM (murine CD38) in in vitro assays. |
| PC-47056 |
ZY-444
Pyruvate carboxylase inhibitor
|
ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway. |
| PC-47038 |
SP-8008
SIPA inhibitor
|
SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation. |
| PC-38900 |
XST-20
FOXM1 inhibitor
|
XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation. |
| PC-38777 |
STK793590
DJ-1/PARK7 inhibitor
|
STK793590 (DJ-1/PARK7 inhibitor 15) is a potent inhibitor of the Parkinson's disease associated protein DJ-1/PARK7 with Kd/IC50 of 0.1/0.28 uM, respectively. |
| PC-38774 |
PXS-5505
pan-LOX inhibitor
|
PXS-5505 is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity. |
