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PSB-KK1415

Chemical Structure : PSB-KK1415

CAS No.: 885896-26-4

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PSB-KK1415 (PSB-KK-1415)

Catalog No.: PC-21097Not For Human Use, Lab Use Only.

PSB-KK1415 is a selective GPR18 agonist with EC50 of 19.1 nM (hGPR18) in β-arrestin recruitment assays, shows no activity against GPR55.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PSB-KK1415 is a selective GPR18 agonist with EC50 of 19.1 nM (hGPR18) in β-arrestin recruitment assays, shows no activity against GPR55.
    PSB-KK1415 displays >25-fold selectivity versus CB receptors, and shows minimal species differences.
    PSB-KK1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.

    Physicochemical Properties

    M.Wt 462.94
    Formula C24H23ClN6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-((2-(1H-indol-3-yl)ethyl)amino)-7-(4-chlorobenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

    References

    1. Fabisiak A, et al. Neurogastroenterol Motil. 2021 Mar;33(3):e14003.
    2. Andhika B Mahardhika, et al. J Med Chem. 2024 Jun 17. doi: 10.1021/acs.jmedchem.3c02423. 

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