| Cat. No. |
Product Name |
Information |
| PC-21254 |
5M-8OH-Q
UGGT inhibitor
|
5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases. |
| PC-21246 |
HAMNO
RPA inhibitor
|
HAMNO (NSC 111847) is a small molecule protein interaction inhibitor of replication protein A (RPA), specifically inhibits RPA DNA binding domain F (DBD-F), inhibits dsDNA unwinding with IC50 of 9 uM. |
| PC-21242 |
Nitisinone
4-HPPD inhibitor
|
Nitisinone (NTBC, Nitisone, SC0735) is a potent, orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with IC50 of 173 nM. |
| PC-21232 |
FMP-201300
IP6K inhibitor
|
FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively. |
| PC-21231 |
Glutamate-cysteine ligase inhibitor EN25
Glutamate-cysteine ligase inhibitor
|
Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL. |
| PC-21228 |
LX-6171
Proline transporter inhibitor
|
LX-6171 is a small molecule proline transporter (SLC6A7) inhibitor with potential for treating cognitive and other disorders. |
| PC-21227 |
LP-403812
Proline transporter inhibitor
|
LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT. |
| PC-21217 |
O-1918
GPR18 antagonist
|
O-1918 is a selective, potent antagonist of non-canonical cannabinoid GPR18, does not bind to CB(1) or CB(2) receptors and does not cause vasorelaxation at concentrations up to 30 uM. |
| PC-21214 |
GPR61 inverse agonist compound 1
GPR61 inverse agonist
|
GPR61 inverse agonist compound 1 is a potent and selective GPR61 inverse agonist with functional IC50 of 10-11 nM in cAMP assays. |
| PC-21207 |
Ticlopidine
CD39 inhibitor
|
Ticlopidine (PCR 5332) is an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM, shows antithrombotic effect. |
| PC-21205 |
ARL67156
ecto-ATPase inhibitor
|
ARL67156 (FPL 67156) is a selective inhibitor of ecto-ATPase, ARL67156 is a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. |
| PC-21193 |
Gliotoxin
LTA4 hydrolase inhibitor
|
Gliotoxin (Aspergillin) is a virulence factor of Aspergillus fumigatus, functions as a potent and selective inhibitor of the epoxide hydrolase activity of LTA4 hydrolase (LTA4H), selectively inhibits LTB4 biosynthesis. |
