AM-3607 | GlyR PAM | Probechem Biochemicals

Chemical Structure : AM-3607

AM-3607 (AM3607)

Catalog No.: PC-23983Not For Human Use, Lab Use Only.

AM-3607 is a potent, positive allosteric modulator of mammalian ionotropic glycine receptor (GlyR) subtypes with EC50 of 25 nM (hGlyRα3β), SPR Kd of 11 nM.

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Biological Activity

AM-3607 is a potent, positive allosteric modulator of mammalian ionotropic glycine receptor (GlyR) subtypes with EC50 of 25 nM (hGlyRα3β), SPR Kd of 11 nM.

Physicochemical Properties

M.Wt	401.44
Formula	C19H19N3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3aS,9bS)-2-(Benzo[d][1,3]dioxol-5-ylsulfonyl)-3,5-dimethyl-3,3a,5,9b-tetrahydro-1H-pyrrolo[3,4-c][1,6]naphthyridin-4(2H)-one

References

1. Bregman H, et al. J Med Chem. 2017 Feb 9;60(3):1105-1125.

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AM-3607 (AM3607)

Biological Activity

Physicochemical Properties

References

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