| Cat. No. |
Product Name |
Information |
| PC-23289 |
C071-0684
CHD1L inhibitor
|
C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells. |
| PC-23287 |
HKi6
HEG1-KRIT1 inhibitor
|
HKi6 is a specific small-molecule HEG1-KRIT1 inhibitor (IC50=1.5 uM) by competing orthosterically with HEG1 for binding to the KRIT1 FERM domain, elevates KLF4 and KLF2 gene expression and increases Akt phosphorylation. |
| PC-23286 |
HKi2
HEG1-KRIT1 inhibitor
|
HKi2 is a specific small-molecule HEG1-KRIT1 inhibitor (IC50=3.5 uM) by competing orthosterically with HEG1 for binding to the KRIT1 FERM domain, elevates KLF4 and KLF2 gene expression and increases Akt phosphorylation. |
| PC-23282 |
Malabaricone C
Sphingomyelin synthase inhibitor
|
Malabaricone C is a natural sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 uM and 1.5 μM for SMS1 and SMS2, respectively. |
| PC-23260 |
Migalastat hydrochloride
α-Gal A inhibitor
|
Migalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of alpha-galactosidase A (α-Gal A) with IC50 of 0.04 uM (human α-Gal A). |
| PC-23220 |
VPS18 inhibitor RDN
VPS18 inhibitor
|
VPS18 inhibitor RDN is a specific lysosomotropic agent that targeting vacuole protein sorting 18 (VPS18), binds to the RING domain of VPS18, leading to disruption of the VPS-C core complex and lysosomal function. |
| PC-23217 |
Steroid sulfatase inhibitor DU-14
Steroid sulfatase inhibitor
|
Steroid sulfatase inhibitor DU-14 is a hihly potent steroid sulfatase inhibitor with IC50 of 55.8 nM, inhibits inhibits the MCF-7 cell proliferation with IC50 of 38.7 nM. |
| PC-23216 |
hPIF1 inhibitor 6
PIF1 inhibitor
|
hPIF1 inhibitor 6 is a specific small molecule inhibitor targeting the helicase activity of human PIF1 with IC50 of 36 uM for inhibition of FLhPIF1 helicase activity, 22-fold selective over hUPF1, inhibits hPIF1 DNA-binding and helicase activity in vitro. |
| PC-23192 |
Swainsonine
Golgi α-mannosidase inhibitor
|
Swainsonine (Tridolgosir) is a natural product indolizidine alkaloid and an inhibitor of the human Golgi α-mannosidase, hGMII (MAN2A1), induces apoptosis and cell cycle arrest at G2/M phase, shows anti-tumor activity. |
| PC-23190 |
NB-115
FOXM1 inhibitor
|
NB-115 is a small molecule FOXM1 inhibitor with Ki of 40 nM and IC50 of 216 nM, suppresses TNBC progression and tumor metastasis. |
| PC-23178 |
SCR-7952
MAT2A inhibitor
|
SCR‐7952 is a potent, highly selective methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 18.7 nM, Ki of 14.49 nM, shows MTAP‐null selective antiproliferative activity. |
| PC-23153 |
GSD-16-24
α-synuclein inhibitor
|
GSD-16-24 is a small molecule inhibitor of amyloid fibrils of α-synuclein (α-syn), binds directly to the C-terminal IDR of α-syn monomer and fibril, preventing the fibril from binding to the receptors. |
