| Cat. No. |
Product Name |
Information |
| PC-60650 |
Ru360
MCU inhibitor
|
Ru360 is a cell-permeable mitochondrial calcium uptake (MCU) inhibitor that binds to mitochondria with high affinity (Kd=340 pM) and blocks Ca2+ uptake into mitochondria in vitro with IC50 of 184 pM. |
| PC-60649 |
AG311
Necrosis inducer
|
AG311 is a first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization. |
| PC-60634 |
APX3330
APE1 inhibitor
|
E3330 (E 3330, APX 3330, APX3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1) redox function (IC50=50 uM), but not APE1 DNA repair activity. |
| PC-60633 |
APX2009
APE1 inhibitor
|
APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition. |
| PC-60631 |
OX03050
Squalene synthase inhibitor
|
OX03050 is a potent, competitive squalene synthase inhibitor that upregulate the LDLR in mouse and human liver cell lines with EC50 of 26 nM. |
| PC-60594 |
Dihydromunduletone
GPR56 INHIBITOR
|
Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs. |
| PC-60560 |
LQB-118
|
LQB-118 is an orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo. |
| PC-60514 |
Fulacimstat
Chymase inhibitor
|
Fulacimstat (BAY 1142524, BAY1142524) is a potent, orally available chymase inhibitor with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively. |
| PC-70232 |
NAPQI
MIF inhibitor
|
NAPQI (N-Acetylimidoquinone) is a toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of macrophage migration inhibitory factor (MIF). |
| PC-70231 |
KIN-1148
IRF3 agonist
|
KIN-1148 (KIN1148) is a small-molecule IRF3 agonist that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. |
| PC-70227 |
WOBE437
Endocannabinoid uptake inhibitor
|
WOBE437 (WOBE-437) is a potent, selective endocannabinoid uptake inhibitor with IC50 of 10 nM, with an outstanding 1,000-fold selectivity over FAAH. |
| PC-70226 |
RX-055
|
RX-055 is tailored WOBE437-derived diazirine-containing photoaffinity probe that irreversibly blocks membrane transport of both endocannabinoids. |
