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SPRi3

Chemical Structure : SPRi3

CAS No.: 1292285-54-1

SPRi3 (SPR inhibitor 3)

Catalog No.: PC-61241Not For Human Use, Lab Use Only.

SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM; also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 uM) without affecting the activity of GCH1; reduces pain hypersensitivity effectively with a concomitant decrease in BH4 levels in target tissues, acting both on sensory neurons and macrophages, with no development of tolerance or adverse effects.

Physicochemical Properties

M.Wt 262.309
Formula C14H18N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl)-2-methoxyacetamide

References

1. Latremoliere A, et al. Neuron. 2015 Jun 17;86(6):1393-406.

2. Cronin SJF, et al. Nature. 2018 Nov;563(7732):564-568.

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