Chemical Structure : SPRi3
CAS No.:
1292285-54-1
SPRi3
(SPR inhibitor 3)
Catalog No.: PC-61241Not For Human Use, Lab Use Only.
SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM; also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 uM) without affecting the activity of GCH1; reduces pain hypersensitivity effectively with a concomitant decrease in BH4 levels in target tissues, acting both on sensory neurons and macrophages, with no development of tolerance or adverse effects.
Physicochemical Properties
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M.Wt
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262.309
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Formula
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C14H18N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl)-2-methoxyacetamide
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References
1. Latremoliere A, et al. Neuron. 2015 Jun 17;86(6):1393-406.
2. Cronin SJF, et al. Nature. 2018 Nov;563(7732):564-568.
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