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Chemical Structure : STOML3 inhibitor OB-1
Catalog No.: PC-61244Not For Human Use, Lab Use Only.
STOML3 inhibitor OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo.
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STOML3 inhibitor OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo.
OB-1 effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin.
OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.
OB-1 also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity.
| M.Wt | 407.382 | |
| Formula | C21H17N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218.
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