STOML3 inhibitor OB-1 |CAS:300803-69-4 Probechem Biochemicals

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Chemical Structure : STOML3 inhibitor OB-1

STOML3 inhibitor OB-1

Catalog No.: PC-61244Not For Human Use, Lab Use Only.

STOML3 inhibitor OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

STOML3 inhibitor OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo.
OB-1 effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin.
OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.
OB-1 also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity.

Physicochemical Properties

M.Wt	407.382
Formula	C21H17N3O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate

References

1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218.

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