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TB-03

Chemical Structure : TB-03

CAS No.: 491831-49-3

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TB-03 (Grb2 SH2 inhibitor TB03)

Catalog No.: PC-61262Not For Human Use, Lab Use Only.

TB-03 is a small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TB-03 is a small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).
TB-03 does not not affect apoptosis alone, enhances imatinib-induced apoptosis and cell cycle suppression, induction of apoptosi.
TB-03 reduced protein tyrosyl phosphorylation and Grb2 recruitment, suppression of a progenitor/stem cell subpopulation and increased expression of relevant tumor suppressor microRNAs.

Physicochemical Properties

M.Wt 708.749
Formula C36H45N4O9P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-((1-(((S)-4-amino-1-((3-(naphthalen-1-yl)propyl)amino)-1,4-dioxobutan-2-yl)carbamoyl)cyclohexyl)amino)-4-oxo-3-(4-(phosphonomethyl)benzyl)butanoic acid

References

1. Zhang M, et al. Leukemia. 2014 Apr;28(4):948-51.

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