| Cat. No. |
Product Name |
Information |
| PC-22916 |
hSR inhibitor 28
Serine racemase inhibitor
|
hSR inhibitor 28 is a potent, selective inhibitor of human serine racemase (SR) with Kd of 5 uM. |
| PC-22915 |
Orziloben
1555822-28-0
|
Orziloben is a novel, orally administered, highly potent, synthetic, medium chain fatty acid analogue (MCFA), shows potential for intestinal failure-associated liver disease (IFALD). |
| PC-22887 |
CD80 inhibitor 6
CD80 inhibitor
|
CD80 inhibitor 6 is a specific small molecule inhibitor of human CD80 with SPR KD of 2.7 nM, antagonize CD28 (TR_FRET EC50=2.4 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays. |
| PC-22886 |
CD80 inhibitor 1
CD80 inhibitor
|
CD80 inhibitor 1 is a specific small molecule inhibitor of human CD80 with SPR KD of 125 nM, antagonize CD28 (TR_FRET EC50=630 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays. |
| PC-22881 |
DPTIP
nSMase 2 inhibitor
|
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM. |
| PC-22870 |
12-deoxyphorbol 13-palmitate
APOL2 inhibitor
|
12-deoxyphorbol 13-palmitate is a potent inhibitor of hepatic stellate cell (HSC) activation, directly and specifically targets apolipoprotein L2 (APOL2). |
| PC-22860 |
GZ667161
Glucosylceramide synthase inhibitor
|
GZ667161 (Genz-667161) is potent, orally available and CNS-penetrant inhibitor of Glucosylceramide synthase (GCS), alleviates aberrations in synucleinopathy models. |
| PC-22844 |
LXG6403
LOX inhibitor
|
LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1. |
| PC-22842 |
SD-066-4
ZDHHC20 inhibitor
|
SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM. |
| PC-22812 |
EHD4 inhibitor MS1
EHD4 inhibitor
|
EHD4 inhibitor MS1 is a small molecule inhibitor of Eps15 Homology Domain Protein 4 (EHD4) with IC50 of 0.92 uM, inhibits Eps15 EHD4's liposome-stimulated ATPase activity. |
| PC-22799 |
BCAT1 inhibitor 2
BCAT1 inhibitor
|
BCAT1 inhibitor 2 (Bi2) is a specific inhibitor of cytosolic branched-chain aminotransferase (BCATc, BCAT1) with IC50 of 0.2/ 0.8 uM for rat/human BCATc respectively, weakly inhibits rat mitochondrial isoenzyme rBCATm. |
| PC-22793 |
BIIB-TTBKi
TTBK inhibitor
|
BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays. |
