| Cat. No. |
Product Name |
Information |
| PC-23529 |
ARI-1
ROR1 inhibitor
|
ARI-1 is a specific inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1), directly targets the frizzled domain with high binding affinity, inhibits EGFR-TKIs-resisted NSCLC with high ROR1 expression. |
| PC-23520 |
Warfarin
VKORC1L1 inhibitor
|
Warfarin (WARF-42, Athrombine-K) is a potent anticoagulant agent and a vitamin K1 recycling antagonist to deplete active vitamin K1, is a small molecular inhibitor of vitamin K epoxide reductase complex subunit 1 like 1 (VKORC1L1). |
| PC-23519 |
Necrocide-1
Necrosis inducer
|
Necrocide-1 (NC1) is a small molecule inducer of tumor necrosis factor (TNF)-independent necrosis, shows antiproliferative activity with IC50 values of 0.48 and 2 nM for MCF-7 and PC3, respectively |
| PC-23518 |
CNOT6L inhibitor iD1
CNOT6L inhibitor
|
CNOT6L inhibitor iD1 (Inhibitor of CNOT6L Deadenylase 1, ICCB-475) is a specific small molecule inhibitor of CCR4-NOT deadenylase subunit CNOT6L with Kd of 7.6 uM and IC50 of 2.5 uM in FRET-based deadenylase assay, modestly inhibits homolog CNOT6 and does not inhibit CNOT7 or CNOT8. |
| PC-23516 |
BC-DXI-843
AIMP2-DX2 inhibitor
|
BC-DXI-843 is a potent and specific AIMP2-DX2 inhibitor with IC50 og 0.92 uM, >100-fold selectivity over AIMP2. |
| PC-23515 |
VP 21-04
HO-1 inhibitor
|
VP 21-04 is a potent, selective Heme oxygenase-1 (HO-1) inhibitor with IC50 of 0.9 uM, displays 42-fold selective over HO-2 (IC50=38 uM). |
| PC-23509 |
SDL01
AIMP2-DX2 inhibitor, DX2-Siah1 modulator
|
SDL01 is a specific small molecule allosteric modulator / enhancer of the interaction between AIMP2-DX2 (DX2) and Siah1, promotes DX2 degradation by Siah1 with IC50 of 1.09 uM in A549 cells. |
| PC-23501 |
CLPP-1071
ClpP agonist
|
CLPP-1071 is a potent, orally efficacious activator of human sapiens caseinolytic protease P (ClpP) with EC50 of 23.5 nM, exhibits HL60 cell growth inhibition with IC50 of 4.6 nM. |
| PC-23500 |
NCA029
ClpP agonist
|
NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with EC50 of 0.2 uM. |
| PC-23499 |
SL44
ClpP agonist
|
SL44 is a potent, small molecule activator /agonist of human caseinolytic protease P (HsClpP) with EC50 of 1.3 uM. |
| PC-23498 |
ClpP activator XT6
ClpP agonist
|
ClpP activator XT6 is a potent human caseinolytic protease P (hClpP) activator with EC50 of 0.08 uM, exhibits good antitumor potency. |
| PC-23497 |
ZG111
ClpP agonist
|
ZG111 is a potent ClpP agonist with EC50 of 1.19 uM, binds to ClpP and promotes the ClpP-mediated degradation of respiratory chain complexes. |
