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CCG-203586

Chemical Structure : CCG-203586

CAS No.: 1430611-24-7

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CCG-203586 (CCG203586)

Catalog No.: PC-61426Not For Human Use, Lab Use Only.

CCG-203586 is a potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCG-203586 is a potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM.
    CCG-203586 inhibits GlcCer production in whole wild-type MDCKII cells with IC50 of 15.3 nM, has little to no apparent recognition by MDR1.
    CCG-203586 significantly and dose-dependently decreases brain glucosylceramide content after intraperitoneal administration in mice.

    Physicochemical Properties

    M.Wt 436.552
    Formula C26H32N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)acetamide

    References

    1. Larsen SD, et al. J Lipid Res. 2012 Feb;53(2):282-91.

    2. Arthur JR, et al. Neurochem Res. 2013 Apr;38(4):866-75.

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