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Ibiglustat

Chemical Structure : Ibiglustat

CAS No.: 1401090-53-6

Ibiglustat (Venglustat, Genz-682452, GZ452, SAR402671, GZ402671)

Catalog No.: PC-61428Not For Human Use, Lab Use Only.

Ibiglustat (Venglustat, Genz-682452) is an orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.

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Biological Activity

Ibiglustat (Venglustat, Genz-682452) is an orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.
Ibiglustat (Venglustat) exhibits significantly lower tissue levels of GL-3 and lyso-GL-3 and a delayed progression of a thermal nociceptive response in administered Fabry mice.
Ibiglustat (Venglustat) shows favorable pharmacological properties and safety profile.

Physicochemical Properties

M.Wt 389.49
Formula C20H24FN3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate

References

1. Ashe KM, et al. Mol Med. 2015 Apr 30;21:389-99.

2. Marshall J, et al. Mol Ther. 2016 Jun;24(6):1019-1029.

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