| Cat. No. |
Product Name |
Information |
| PC-70005 |
Gue-1654
OXE-R inhibitor
|
Gue-1654 (GUE 1654) is a small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R (Oxoeicosanoid receptor) in both recombinant and human primary cells. |
| PC-70001 |
C1632
Lin28 inhibitor
|
C1632 (Lin28-IN-1632) is a small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells. |
| PC-60090 |
trans-AUCB
sEH inhibitor
|
trans-AUCB is a potent, specific and orally bioavailable soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM. |
| PC-60018 |
RU.521
cGAS inhibitor
|
RU.521 (RU521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM. |
| PC-42914 |
PFK-158
PFKFB3 inhibitor
|
PFK-158 is the first potent, selective and competitive small molecule inhibitor of PFKFB3 with IC50 of 137 nM, inhibits glycolysis, induces apoptosis and autophagy. |
| PC-47499 |
Tat-NR2B9c
PSD-95 inhibitor
|
Tat-NR2B9c (NA-1) is a neuroprotective agent, exhibits high-affinity binding to the second PDZ domain of PSD-95, inhibits NR2A-NR2C/PSD-95 interactions (IC50=1-10 uM) and nNOS/PSD-95 interaction (IC50=200 nM). |
| PC-45661 |
MCB-613
SRC stimulator
|
MCB-613 is a potent steroid receptor coactivator (SRC1, SRC2 and SRC3) stimulator. |
| PC-45685 |
Emixustat hydrochloride
RPE65 inhibitor
|
Emixustat (ACU-4429) hydrochloride is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM. |
| PC-45684 |
Emixustat
RPE65 inhibitor
|
Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM. |
| PC-45670 |
BRD7552
PDX1 inducer
|
BRD7552 is a small-molecule inducer of pancreatic and duodenal homeobox 1 (PDX1) expression, induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. |
| PC-47504 |
ARA290
Erythropoietin/CD131 agonist
|
ARA290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative, specific agonist of erythropoietin/CD131 heteroreceptor, improves insulin release and glucose tolerance in type 2 diabetic GK rats. |
| PC-45840 |
Azeliragon
RAGE inhibitor
|
Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor of RAGE, inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine. |
