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ZINC 39395747

Chemical Structure : ZINC 39395747

CAS No.: 1801163-44-9

ZINC 39395747 (ZINC39395747, ZINC-39395747)

Catalog No.: PC-60880Not For Human Use, Lab Use Only.

ZINC 39395747 is a novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM.

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    Biological Activity

    ZINC 39395747 is a novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM.
    ZINC 39395747 significantly increases NO bioavailability in renal vascular cells, augments renal blood flow, and decreases systemic blood pressure in response to vasoconstrictors in spontaneously hypertensive rats.

    Physicochemical Properties

    M.Wt 293.359
    Formula C12H11N3O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-6-(((2,3-dihydrobenzo[d]oxazol-2-yl)thio)methyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

    References

    1. Rahaman MM, et al. J Biol Chem. 2015 Jul 3;290(27):16861-72.

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