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DS-1040 tosylate hydrate

Chemical Structure : DS-1040 tosylate hydrate

CAS No.: 1335138-90-3

DS-1040 tosylate hydrate (DS 1040;DS1040)

Catalog No.: PC-61011Not For Human Use, Lab Use Only.

DS-1040 tosylate hydrate (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DS-1040 tosylate hydrate (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa; a novel fibrinolysis-enhancing agent has favorable pharmacokinetic/pharmacodynamic properties and a favorable safety profile

Stroke

Phase 2 Clinical

Physicochemical Properties

M.Wt 483.624
Formula C23H37N3O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-5-amino-2-((1-((1r,4S)-4-methylcyclohexyl)-1H-imidazol-4-yl)methyl)pentanoic acid compound with 4-methylbenzenesulfonic acid (1:1) hydrate

References

1. Zhou J, et al. J Thromb Haemost. 2017 May;15(5):961-971.

2. Gurewich V, et al. J Thromb Haemost. 2017 Oct;15(10):2080-2081.

3. Paul A Lapchak, et al. Abstract WP282: DS-1040 an Inhibitor of the Activated Thrombin Activatable Fibrinolysis Inhibitor Improves Behavior in Embolized Rabbits, Stroke. 2016;47:AWP282.

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