DS79182026 | Hepcidin inhibitor | Probechem Biochemicals

Chemical Structure : DS79182026

DS79182026 (DS 79182026, DS-79182026)

Catalog No.: PC-61013Not For Human Use, Lab Use Only.

DS79182026 (DS-79182026) is a potent, orally active hepcidin production inhibitor with IC50 of 39 nM, with low kinase inhibitory activity.

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Biological Activity

DS79182026 (DS-79182026) is a potent, orally active hepcidin production inhibitor with IC50 of 39 nM, with low kinase inhibitory activity.
DS79182026 inhibits hepcidin production in HepG2 cell, slowers serum hepcidin in mouse IL-6 induced acute inflammatory model.

Physicochemical Properties

M.Wt	349.35
Formula	C18H15N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (6-(5-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)benzo[d]isoxazol-3-yl)carbamate

References

1. Fukuda T, et al. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3716-3722.

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DS79182026 (DS 79182026, DS-79182026)

Biological Activity

Physicochemical Properties

References

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