| Cat. No. |
Product Name |
Information |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-26468 |
NCGC00238624
GALK1 inhibitor
|
NCGC00238624 is a highly selective galactokinase (GALK1) inhibitor with IC50 of 7.69 and 13.67 uM against the human and mouse recombinant GALK1, respectively, lowers gal-1P levels in primary fibroblast cells derived from patients with classic galactosemia. |
| PC-26467 |
GALK1-IN-1
GALK1 inhibitor
|
GALK1-IN-1 is an effective ATP-competitive galactokinase 1 (GALK1) inhibitor with IC50 of 1 uM in luminescence GALK-ATP-depletion assay. |
| PC-26455 |
Z1692774161
ROBO2 binder
|
Z1692774161 is a small molecule ligand of Roundabout homolog 2 (ROBO2), bind ROBO2 in a reproducible concentration-dependent manner with KD of 25.8 uM. |
| PC-26454 |
SMEI inhibitor 20e
SMEI inhibitor
|
SMEI inhibitor 20e is a small molecule inhibitor targeting SCN1A-associated severe myoclonic epilepsy of infancy (SMEI), shows potent antiseizure efficacy in zebrafish behavioral assays and significantly reduces locomotion-related seizure parameters, elevates 5-HT levels via TPH2 upregulation. |
| PC-26450 |
ACSS2-IN-1
ACSS2 inhibitor
|
ACSS2-IN-1 is a higly potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.01 nM to <1 nM. |
| PC-26445 |
PON2 inhibitor 2
PON2 inhibitor
|
PON2 inhibitor 2 is a potent, specific small molecule inhibitor of paraxonase 2 (PON2) with IC50 of 56 nM, inhibits the lactonase activity of PON2. |
| PC-26444 |
TQ416
PON2 inhibitor
|
TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death. |
| PC-26435 |
IDE activator Ia2
IDE activator
|
IDE activator Ia2 (IDE activator 2) is a potent, selective activator of insulin degrading enzyme (IDE), the hydrolysis of SP1 and FRET1 by IDE, significantly stimulates IDE proteolytic activity. |
| PC-26434 |
IDE activator Ia1
IDE activator
|
IDE activator Ia1 (IDE activator 1) is a potent, selective activator of insulin degrading enzyme (IDE), activates the hydrolysis of SP1 and FRET1 by IDE to ∼200% and ∼500%, activates the degradation of Aβ by ∼700%. |
| PC-26433 |
IDE inhibitor Ii1
IDE inhibitor
|
IDE inhibitor Ii1 (IDE inhibitor 1) is a potent, selective inhibitor of insulin degrading enzyme (IDE) with Ki of 1.7 nM. |
| PC-26432 |
BDM35899
IDE activator
|
BDM35899 is a small activator of insulin degrading enzyme (IDE) with pEC50 of 5.3, binds to polyanion-binding site of IDE, activates both Aβ and insulin hydrolysis by IDE, decreases glucose-stimulating insulin secretion in β-pancreatic cells. |
