| Cat. No. |
Product Name |
Information |
| PC-26316 |
VRK1 inhibitor Compound 1
VRK1 inhibitor
|
VRK1 inhibitor Compound 1 (VRK1-IN-1) is a potent, selective and ATP-competitive inhibitor of Vaccinia-related kinase 1 (VRK1) with Ki of 82 nM and IC50 of 154 nM, selective for VRK1 over VRK2. |
| PC-26308 |
GIT1/β-Pix inhibitor 14-5-18
GIT1/β-Pix inhibitor
|
GIT1/β-Pix inhibitor 14-5-18 is a small-molecule inhibitor to interrupt the protein–protein interaction (PPI) of GIT1/β-Pix complex with Ki of 1.8 uM in FP assays, directly binds to GIT1 with BLI KD of 7.7 uM, inhibits gastric cancer metastasis. |
| PC-26307 |
JX24120
MAT2B inhibitor
|
JX24120 is a specific inhibitor for methionine adenosyltransferase MAT2B, directly binds to MAT2B with SPR KD of 4.72 uM, inhibits S-adenosylmethionine (SAMe) synthesis. |
| PC-26306 |
GIT1 inhibitor Compound 3
GIT1 inhibitor
|
GIT1 inhibitor Compound 3 (GIT1-IN-C3) is a selective small molecule inhibitor of ARF GTPase protein 1 (GIT1) with MST KD of 6.2 uM, effectively disrupts GIT1 from interacting with MAT2B and RAF/MEK/ERK to halt cancer cell growth in vitro and in vivo. |
| PC-26292 |
STK189682
RNA helicase inhibitor
|
STK189682 is a potent small molecule inhibitor of RNA helicases MDA5, LGP2, and DDX1 with IC50 of 7 uM, 7 uM and 5 uM in ATPase assays. |
| PC-26291 |
UNC11676A
MDA5 inhibitor
|
UNC11676A is a specific small molecule inhibitor of RNA helicase MDA5 with IC50 of 6 uM, >18-fold selective inhibition over LGP2 and DDX1. |
| PC-26275 |
Rebaudioside N
SBK2 agonist
|
Rebaudioside N is a terpenoid glycoside isolated from the leaves of Stevia rebaudiana Bertoni, is a potent SH3 domain-binding kinase 2 (SBK2) agonist, effectively suppresses NLRP3-mediated IL-1β/IL-18 secretion, reduces inflammatory responses, and diminishes atherosclerotic burden. |
| PC-26272 |
CZ-2401
TRIM47-HNF4α inhibitor
|
CZ-2401 is a potent, specific inhibitor of the TRIM47-HNF4α interaction, binds to HNF4α with MST Kd of 2.52 uM, stabilizes HNF4α protein and activates HNF4α transcriptional activity. |
| PC-26260 |
Bufotalin
COL1A1 inhibitor
|
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities, a selective and potent inhibitor of COL1A1-high NSCLC. |
| PC-26246 |
Carbutamide
339-43-5
|
Carbutamide (BZ-55) is Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity. |
| PC-26242 |
E8431
DCSTAMP antagonist
|
E8431 (Z2371498431) is a specific small molecule antagonist of fusogenic protein DCSTAMP, disrupts DCSTAMP-RAP1B interaction and inhibits RAP1-RAC1 signaling-mediated cytoskeletal reorganization required for osteoclast maturation and fusion, demonstrats significant osteoclastogenesis inhibition (IC50=0.7758 μM) without cytotoxic effects on mBMMs. |
| PC-26237 |
HF13141-H5
GGCX inhibitor
|
HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect. |
