| Cat. No. |
Product Name |
Information |
| PC-25556 |
α-difluoromethylornithine
Ornithine decarboxylase inhibitor
|
α-difluoromethylornithine (DFMO, Eflornithine, MDL71782) is a specific, irreversible inhibitor of polyamine biosynthesis enzyme Ornithine decarboxylase (ODC) with biochemicals IC50 of 252 uM, binding competitively with ornithine. |
| PC-25540 |
Ezurpimtrostat hydrochloride
PPT1 inhibitor
|
Ezurpimtrostat hydrochloride (GNS561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-25528 |
MDOLL-0286
ARH3 inhibitor
|
MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1. |
| PC-25466 |
MASTL inhibitor MKI-2
Greatwall inhibitor
|
MKI-2 (MASTL kinase inhibitor-2) is a potent small molecule inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall/GWL), inhibits recombinant MASTL activity and cellular MASTL activity with IC50 of 37.44 nM and 142.7 nM, respectively. |
| PC-25458 |
DH20931
CerS2 agonist
|
DH20931 is a first-in-class, potent small-molecule agonist of Ceramide Synthase 2 (CerS2) with activation constant (Kact) of 16.54 nM, exhibits potent, broad-spectrum, and receptor-independent antitumor activity in vitro and in vivo. |
| PC-25450 |
RTI-19318-32
GPR3 agonist
|
RTI-19318-32 is a potent, specific full agonist of G protein-coupled receptor 3 (GPR3) with EC50 of 260 nM and Emax of 90%. |
| PC-25446 |
G4451
GPR31 inhibitor
|
G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression. |
| PC-25445 |
RGX-202
SLC6A8 inhibitor
|
RGX-202 (RGX202, Ompenaclid, β-guanidinoproprionic acid) is an oral small-molecule creatine mimetic inhibitor of creatine transporter SLC6A8, inhibits cellular creatine import and suppresses intracellular phosphocreatine, creatine, and ATP levels, exhibits broad antitumor activity against diverse primary and metastatic CRCs. |
| PC-25443 |
UCB1244283
SV2A modulator
|
UCB1244283 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A), selective over SV2B and SV2C, enhances brivaracetam (BRV) binding by occupying an allosteric site near the primary binding site, preventing BRV dissociation. |
| PC-25442 |
UCB7361
SV2A modulator
|
UCB7361 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A). |
| PC-25437 |
EN020
TREM2 modulator
|
EN020 is a novel small molecule modulator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 14.2 µM (MST) and 35.9 µM (SPR), significantly enhances microglial phagocytosis in BV2 cells. |
| PC-25436 |
TREM2 agonist As48
TREM2 agonist
|
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis. |
