| Cat. No. |
Product Name |
Information |
| PC-27087 |
S428-1145
PUS7 inhibitor
|
S428-1145 is a small molecule inhibitor targeting pseudouridine synthase 7 (PUS7), has anti-proliferative IC50 of 20 µM in MIA PaCa-2 cells and 20.68 µM in PANC-1 cells, respectively, significantly inhibits tumour growth. |
| PC-27049 |
SB-583355
GPR132 antagonist
|
SB-583355 is a potent, peptidomimetic inhibitor of GPR132 (G2A), inhibits agonist-induced hGPR132aPL association with β-arrestin with pIC50 of 7.0. |
| PC-27047 |
SKF-95667
GPR132 agonist
|
SKF-95667 is a potent, selective agonist of G-protein-coupled receptor GPR132 (G2A) with pEC50 of 6.6 and 5.8 in yeast and β-arrestin assays (human GPR132a). |
| PC-27046 |
GSK1820795A
GPR132 antagonist
|
GSK1820795A is a potent, specific antagonist of G-protein-coupled receptor GPR132 (G2A), blocks agonist-induced association of hGPR132 with β-arrestin with pIC50 of 7.8, also is a dual angiotensin AT1 antagonist and PPARγ modulator. |
| PC-26951 |
AGPS-IN-1
AGPS inhibitor
|
AGPS-IN-1 (AGPS inhibitor 2i) is a small molecule inhibitor of alkylglyceronephosphate synthase (AGPS), decreases ether lipids, cell migration and survival, specifically impairs EMT through E-cadherine, Snail, Mmp2 modulation. |
| PC-26922 |
GPR52 agonist R-185
GPR52 agonist
|
GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice. |
| PC-26919 |
SSKP-0076
Ybx1 inhibitor
|
SSKP-0076 is a small molecule inhibitor of Y-box binding protein 1 (Ybx1), inhibits invasion and migration of LM8 osteosarcoma cells. |
| PC-26881 |
SIH-001
ZMIZ1 inhibitor
|
SIH-001 is a specific small-molecule inhibitor of ZMIZ1 (Zinc finger MIZ domain-containing protein 1) with SPR KD of 0.498 uM. |
| PC-26872 |
CPN-219
NMUR2 agonist
|
CPN-219 is a potent, selective, next-generation hexapeptidic neuromedin U receptor type 2 (NMUR2) agonist with EC50 value of 2.2 nM. |
| PC-26814 |
HMGCS1 inhibitor CNP7
HMGCS1 inhibitor
|
CNP7 is a potent, selective, covalent HMG-CoA synthase 1 (HMGCS1) inhibitor, reduces HMG-CoA levels and global protein prenylation. |
| PC-26793 |
MDC134
Insulinotropic molecule
|
MDC134 is a glucose-dependent insulinotropic small molecule that enhances β-cell insulin secretion in pancreatic β-cells through Ca2+ influx and cAMP-associated amplification. |
| PC-26779 |
(Z)-Ligustilide
CAS 81944-09-4
|
(Z)-Ligustilide is an orally active natural compound from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD). |
