| Cat. No. |
Product Name |
Information |
| PC-25479 |
SF-153
UHM splicing factor inhibitor
|
SF-153 is a small molecule inhibitor of UHM splicing factor RBM39 and SPF45 with IC50 of 45.8 uM for both, targets U2 Auxiliary Factor Homology Motif (UHM) domains, exerts anti-tumor activities in leukemia cell lines. |
| PC-25465 |
Greatwall inhibitor C-604
Greatwall inhibitor
|
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays. |
| PC-25458 |
DH20931
CerS2 agonist
|
DH20931 is a first-in-class, potent small-molecule agonist of Ceramide Synthase 2 (CerS2) with activation constant (Kact) of 16.54 nM, exhibits potent, broad-spectrum, and receptor-independent antitumor activity in vitro and in vivo. |
| PC-25450 |
RTI-19318-32
GPR3 agonist
|
RTI-19318-32 is a potent, specific full agonist of G protein-coupled receptor 3 (GPR3) with EC50 of 260 nM and Emax of 90%. |
| PC-25446 |
G4451
GPR31 inhibitor
|
G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression. |
| PC-25445 |
RGX-202
SLC6A8 inhibitor
|
RGX-202 (RGX202, Ompenaclid, β-guanidinoproprionic acid) is an oral small-molecule creatine mimetic inhibitor of creatine transporter SLC6A8, inhibits cellular creatine import and suppresses intracellular phosphocreatine, creatine, and ATP levels, exhibits broad antitumor activity against diverse primary and metastatic CRCs. |
| PC-25443 |
UCB1244283
SV2A modulator
|
UCB1244283 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A), selective over SV2B and SV2C, enhances brivaracetam (BRV) binding by occupying an allosteric site near the primary binding site, preventing BRV dissociation. |
| PC-25442 |
UCB7361
SV2A modulator
|
UCB7361 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A). |
| PC-25434 |
KDS12025
Hb pseudoperoxidase enhancer
|
KDS12025 is a specific, BBB-permeable small molecule that enhances hemoglobin (Hb) pseudoperoxidase activity 100-fold (EC50=0.04 uM), enabling effective H2O2 decomposition even at extremely low Hb levels. |
| PC-25386 |
Ceranib-2
Ceramidase inhibitor
|
Ceranib-2 (Ceranib2) is a small molecule ceramidase inhibitor with IC50 of 28 uM in cell-based assays, exhibits antiproliferative effect in SKOV3 cells with IC50 of 0.71 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25385 |
Ceranib-1
Ceramidase inhibitor
|
Ceranib-1 (Ceranib1) is a small molecule ceramidase inhibitor, exhibits antiproliferative effect in SKOV3 cells with IC50 of 4.1 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25362 |
Dracorhodin perchlorate
CD147 inhibitor
|
Dracorhodin perchlorate is a potent CD147 inhibitor that induces autophagy-dependent degradation, triggers PUFA/MUFA balance-mediated ferroptosis. |
