| Cat. No. |
Product Name |
Information |
| PC-27512 |
MAT2A inhibitor ZS34
MAT2A inhibitor
|
MAT2A inhibitor ZS34 is a potent, selective, and orally bioavailable MAT2A inhibitor with IC50 of 13.7 nM. |
| PC-27508 |
Tazbentetol
Synaptic regenerative agent
|
Tazbentetol (SPG302) is a pegylated benzothiazole derivative and synaptic regenerative small molecule, targets the cytoskeleton and induces the formation of new glutamatergic synapses. |
| PC-27505 |
JXL069
MPC inhibitor
|
Suvomipic (JXL069) is a potent, small molecule mitochondrial pyruvate carrier (MPC) inhibitor with IC50 of 42.8 nM. |
| PC-27499 |
AKBA
MAT2A inhibitor
|
AKBA is a bioactive boswellic acid found in frankincense and allosteric, specific inhibitor of methionine adenosyltransferase 2A (MAT2A) with MST Kd of 129 nM, shows anti-inflammatory and anti-cancer properties. |
| PC-27497 |
SARM1 inhibitor MY-13B
SARM1 inhibitor
|
SARM1 inhibitor MY-13B is a stereoselective, covalent SARM1 inhibitor, site-specifically engage C311 in SARM1. |
| PC-27492 |
Rexipictor
Polycystin-1 corrector
|
Rexipictor (VX-407) is a first-in-class small molecule Polycystin-1 (Polycystin 1, PC1, PKD1) corrector, corrects inappropriate PC1 folding to abate cystogenesis and eGFR decline, shows potential for treatment of autosomal dominant polycystic kidney disease (ADPKD). |
| PC-27442 |
FSG67
GPAT inhibitor
|
FSG67 is a small molecule mitochondrial glycerol-3-phosphate acyltransferase (mitochondrial GPAT, GPAM) inhibitor with IC50 30.2 μM for total mitochondrial GPAT and 42.1 μM for GPAT1. |
| PC-27422 |
3,4,3-LI(1,2-HOPO)
Chelating agent
|
3,4,3-LI(1,2-HOPO) (Enfipaxetan) is a metal chelating agent, exhibits extremely high affinity for lanthanide metal ions, sensitizes the emission of Sm(III), Eu(III), and Tb(III) in the Visible range and the emission of Pr(III), Nd(III), Sm(III), and Yb(III). |
| PC-27404 |
Alcedaplin
APOL1 inhibitor
|
Alcedaplin (MZE829) is a small molecule inhibitor of apolipoprotein L1 (APOL1) function, blocks APOL1 pore function and ameliorate manifestations of APOL1-mediated kidney disease (AMKD). |
| PC-27301 |
PHB1 inhibitor TD6
Prohibitin 1 inhibitor
|
PHB1 inhibitor TD6 is a highly potent and selective small-molecule inhibitor of Prohibitin 1 (PHB1), exerts potent anti-tumor activities against CRC, effectively suppresses tumor growth and dissemination by disrupting mitochondrial energy metabolism. |
| PC-27294 |
LRPPRC inhibitor 3o
LRPPRC inhibitor
|
LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation. |
| PC-27293 |
FKA-9i
LRPPRC-YBX1-RPN1 inhibitor
|
FKA-9i is a potent broad-spectrum anticancer agent, directly binds to leucine-rich PPR motif-containing protein (LRPPRC), Y-box binding protein 1 (YBX1), and ribophorin I (RPN1) with 7.387 μM, 26.82 μM, and 16.52 μM, respectively, reducing their interactions and stability. |
