Catalog No.: PC-21174Not For Human Use, Lab Use Only.
Kisspeptin 234 (Peptide 234, P234) is a potent kisspeptin receptor (KISS1, GPR54) antagonist antagonist with binding IC50 of 2.7 nM in competition with 125I-kisspeptin-10, blocks the stimulatory effects of kisspeptin on hypothalamus-pituitary-gonadal (HPG) axis.
Kisspeptin 234 (Peptide 234, P234) is a potent kisspeptin receptor (KISS1, GPR54) antagonist antagonist with binding IC50 of 2.7 nM in competition with 125I-kisspeptin-10, blocks the stimulatory effects of kisspeptin on hypothalamus-pituitary-gonadal (HPG) axis.
Peptide P234 potently inhibits 10 nM kisspeptin-10 stimulation of IP by 93%, with an IC50 of 7 nM and has no intrinsic IP stimulation.
Peptide 234 (1 nM) antagonizes kisspeptin-10 excitation of GnRH neurons.
Peptide 234 inhibits pulsatile GnRH release in pubertal female rhesus monkeys.
Peptide 234 inhibits kisspeptin-10 stimulated LH in intact male rats and the increase in LH after castration.
Physicochemical Properties
M.Wt
1409.43
Formula
C65H79F3N18O15
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Ac-Ala-Asn-Trp-Asn-Gly-Phe-Gly-Trp-Arg-Phe-NH2 TFA salt
References
1. Fariba Mahmoudi, et al. Int J Endocrinol Metab. 2014 Jan 5;12(1):e12554.
2. Antonia K Roseweir, et al. J Neurosci. 2009 Mar 25;29(12):3920-9.
