Cat. No. |
Product Name |
Information |
PC-72578 |
AGX51
Id poteins inhibitor
|
AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids. |
PC-72576 |
SAFit1
FKBP51 inhibitor
|
SAFit1 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 4 nM, >10,000-fold selectivity over FKBP52. |
PC-72575 |
SAFit2
FKBP51 inhibitor
|
SAFit2 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 6 nM, >10,000-fold selectivity over FKBP52. |
PC-72561 |
GNS561
PPT1 inhibitor
|
GNS561 (Ezurpimtrostat, GNS-561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
PC-72555 |
TET inhibitor C35
TET inhibitor
|
TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome. |
PC-72551 |
CTPS-IN-T35
CTPS inhibitor
|
CTPS-IN-T35 is a potent, small molecule inhibitor of CTPS (cytidine triphosphate synthase) with IC50 of 4.7/25.7 nM against CTPS1/2 in RapdFire MS assays. |
PC-72547 |
SG-094
TPC2 inhibitor
|
SG-094 (SG094) is a specific cytostatic two-pore channel 2 (TPC2) inhibitor with IC50 of 8.3 uM (TPC2 activator TPC2-A1-P inhibition), shows antiproliferative effect on RIL175 cells with IC50 of 3.7 uM. |
PC-72538 |
GSK-983
DHODH inhibitor
|
GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM. |
PC-72523 |
Omilancor
LANCL2 agonist
|
Omilancor (BT-11) is a locally-acting, first-in-class, small molecule that selectively activates the Lanthionine Synthetase C-like 2 (LANCL2) pathway. |
PC-72520 |
BAY-179
Complex I inhibitor
|
BAY-179 (BAY179) is a potent, selective, and species cross-reactive Complex I inhibitor with IC50 of 79 nM. |
PC-72515 |
ELOVL1-IN-22
ELOVL1 inhibitor
|
ELOVL1-IN-22 is a potent, selective, CNS-penetran inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme, reduces C26:0 VLCFA synthesis in HEK293 with EC50 of 0.4 nM. |
PC-72501 |
JH-RE-06
REV1-REV7 inhibitor
|
JH-RE-06 is a potent REV1-REV7 interface inhibitor (IC50=0.78 uM, Kd=0.42 uM) that disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ, induces REV1 dimerization and blocks POLζ recruitment. |