| Cat. No. |
Product Name |
Information |
| PC-49029 |
PSB-CB-27
GPR18 antagonist
|
PSB-CB-27 is a potent, selective antagonist of GPR18 with IC50 of 650 nM, shows no inhibition on GPR55 and low affinity for CB1/CB2 receptors. |
| PC-49028 |
PSB-CB5
GPR18 antagonist
|
PSB-CB5 is a potent, selective antagonist of GPR18, inhibits GPR18 activation by tetrahydrocannabinol (THC) with IC50 of 279 nM in β-arrestin recruitment assays. |
| PC-49016 |
VSW1198
GGDPS inhibitor
|
VSW1198 is a potent, selective geranylgeranyl diphosphate synthase (GGDPS) inhibitor with IC50 of 45 nM, VSW1198 is highly specific for GGDPS over other enzymes in the isoprenoid biosynthesis (IBP) pathway. |
| PC-49007 |
KBP-066
Amylin/Calcitonin receptor agonist
|
KBP-066 is a potent, selective dual amylin and calcitonin receptor agonist induces an equally potent body weight loss across a broad dose range in obese rats. |
| PC-49001 |
MS21570
GPR171 antagonist
|
MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM). |
| PC-47110 |
MS0015203
GPR171 agonist
|
MS0015203 (MS15203) is a potent, selective small-molecule agonist of neuropeptide receptor GPR171 with binding IC50 of 81 nM (WT GPR171). |
| PC-47092 |
RG100204
AQP9 inhibitor
|
RG100204 is a novel selective, small molecule inhibitor of the neutral solute channel Aquaporin 9 (AQP9), inhibits AQP9 water permeability (IC50=110 nM) and AQP9 glycerol permeability (IC50=76 nM). |
| PC-47091 |
UNC5452
Nek1 inhibitor
|
UNC5452 is a selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 4.3 uM. |
| PC-47087 |
IL-17A PPIm 23
IL-17A modulator
|
IL-17A PPIm 23 is a potent, orally bioavailable, small-molecule protein-protein interaction modulator (PPIm) of IL-17A, shows potential treatment of psoriasis and other inflammatory diseases. |
| PC-47085 |
RG3039
DcpS inhibitor
|
RG3039 (PF-06687859) is a potent, orally bioavailable and brain-penetrant inhibitor of the ribonucleic acid scavenger enzyme DcpS with IC50 of 3.4 nM. |
| PC-47083 |
TH10785
OGG1 activator
|
TH10785 is a small-molecule activator of 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), increases the enzyme activity 10-fold, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage in cells. |
| PC-47075 |
GBT1118
Hemoglobin modifier
|
GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain. |
