| Cat. No. |
Product Name |
Information |
| PC-26075 |
TeGG
UGT1A1 inhibitor
|
1,2,3,6-Tetragalloylglucose (TeGG) is a substrate competitive inhibitor of UDP-glucuronyltransferase UGT1A1, inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 uM and 4.31 uM, respectively. |
| PC-26070 |
APL-4098
GCN2 inhibitor
|
APL-4098 is a potent, selective, ATP-binding site competitive GCN2 inhibitor with Ki of 4.39 nM in TR-FRET assays. |
| PC-26065 |
PSMA-617
PSMA inhibitor
|
PSMA-617 (Vipivotide tetraxetan) is a potent, high affinity prostate-specific membrane antigen (PSMA) inhibitor with Ki of 0.37 nM. |
| PC-26035 |
SecA activator HSI6
SecA activator
|
SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states. |
| PC-26024 |
BPU17
Prohibitin inhibitor
|
BPU17 is a specific small molecule inhibitor of prohibitin, binds to prohibitin 1 (PHB1) and inhibits the PHB1-PHB2 interaction, inhibits epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) and exhibits antifibrotic activity in vivo. |
| PC-26013 |
GPR83 agonist CPD1
GPR83 agonist
|
GPR83 agonist CPD1 is a potent, selective small molecule GPR83 agonist with binding IC50 of 10 nM, induces dose-dependent increases in intracellular Ca+2 release in CHO cells expressing mouse GPR83 with EC50 of 74 nM. |
| PC-26012 |
GPR83 antagonist CPD25
GPR83 antagonist
|
GPR83 antagonist CPD25 is a potent, selective GPR83 antagonist with IC50 of 7 nM. |
| PC-26005 |
GS-1291269
Ketohexokinase inhibitor
|
GS-1291269 is a potent, selective and neutral ketohexokinase (KHK) inhibitor, with IC50 of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. |
| PC-26000 |
Iodomethylcholine
CutC/D inhibitor
|
Iodomethylcholine (IMC) is a highly potent non-lethal, irreversible and non-competitive TMA-generating enzyme CutC/D inhibitor with IC50 of 1.2 nM against Proteus mirabilis CutC/D, reduces TMAO levels in vivo. |
| PC-25999 |
Fluoromethylcholine
TMA Lyase inhibitor
|
Fluoromethylcholine (FMC) is a highly potent TMA Lyase inhibitor in Escherichia coli (IC50 = 900 pM against Proteus mirabilis CutC/D) and in a polymicrobial human fecal culture (IC50 = 7.9 nM). |
| PC-25996 |
ADAR1i-124
ADAR1 inhibitor
|
ADAR1i-124 is a selective inhibitor of the ADAR1 A-to-I RNA editing activity with in vitro editing IC50 values of 10-30 uM, inhibits the catalytic activities of both ADAR1p150 and ADAR1p110. |
| PC-25994 |
LP-856866
ACSL5 inhibitor
|
LP-856866 (ACSL5i) is a potent, selective inhibitor of Acyl-CoA Synthetase 5 (ACSL5) with IC50 of 4 nM and 8 nM for huamn and mouse ACSL5 in acyl-CoA synthetase (ACS) assays, highly selective against ACSL3. |
