| Cat. No. |
Product Name |
Information |
| PC-49739 |
MS0621
EWSR1::FLI1 modulator
|
MS0621 (UNC0621, MS 0621) is a small-molecule modulator of EWSR1::FLI1-mediated chromatin, reverses EWSR1::FLI1-mediated chromatin accessibility, persistently and selectively inhibits cell proliferation in Ewing sarcoma cell lines (SK-N-MC, IC50=128 nM). |
| PC-49735 |
Lixumistat
OXPHOS inhibitor
|
IM156 (Lixumistat, HL156A, IM-156) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin. |
| PC-49731 |
trans-MiM111
Mitofusin activator
|
trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93). |
| PC-49730 |
CPR1-B
Mitofusin activator
|
CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%). |
| PC-49721 |
SBT-272
Cardiolipin stablizer
|
SBT-272 (Bevemipretide) is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in inner mitochondrial membrane (IMM), thereby restoring mitochondrial structure and respiratory function. |
| PC-49719 |
EPI-589
Oxidoreductase inhibitor
|
EPI-589 (EPI 589) is an orally available, blood-brain barrier permeable redox-active agent characterized by highly potent protective effects against oxidative stress, attenuates oxidative stress due to the radical scavenging activity of the reduced form and affects mitochondrial energy metabolism as a substrate of quinone-oxidoreductases. |
| PC-49704 |
NUP-17d-52A
Plek2 inhibitor
|
NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM). |
| PC-49703 |
Plek2 inhibitor NUP-17d
Plek2 inhibitor
|
Plek2 inhibitor NUP-17d is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2 and Plek2-DEP with high affinity (ITC KD=109 and 350 nM, respectively). |
| PC-49693 |
Xist inhibitor X1
Xist inhibitor
|
Xist inhibitor X1 is a selective small molecule inhibitor of the non-coding RNA prototype Xist function, binds specifically to the RepA motif of Xist (Kd=0.4 uM) in vitro and in vivo. |
| PC-49692 |
VPS41 inhibitor DMBP
VPS41 inhibitor
|
DMBP is a natural small molecule with preferable anticancer activity, inhibits vacuolar protein sorting-associated protein 41 homolog (VPS41) function, a subunit of the HOPS complex. |
| PC-49685 |
MPO inhibitor IN-4
MPO inhibitor
|
MPO inhibitor IN-4 is a highly potent, selective, irreversible and orally bioavailable myeloperoxidase (MPO) inhibitor. |
| PC-49677 |
PDS-0330
Claudin-1 inhibitor
|
PDS-0330 (PDS0330) is a first-generation, specific small molecule claudin-1 inhibitor with Kd of 22.9 uM in MST binding assays, impairs the interaction between claudin1 and pSrc/Src and alters survival signaling pathways. |
