| Cat. No. |
Product Name |
Information |
| PC-22683 |
FR900359
Gq/11 inhibitor
|
FR900359 is a plant-derived depsipeptide and specific pan-Gq (Gq/11/14) inhibitor, selectively inhibits Gq-dependent signalling, with little effect on Galphasbetagamma, Galphaibetagamma, or Galpha12/13betagamma heterotrimer activity. |
| PC-22682 |
Hymeglusin
HMGCS1 inhibitor
|
Hymeglusin is a fungal β-lactone antibiotic and HMG-CoA synthase 1 (HMGCS1) inhibitor with IC50 of 0.12 uM, suppresses the growth of AML cells and enhances their chemosensitivity. |
| PC-22678 |
DS28120313
Hepcidin inhibitor
|
DS28120313 is a potent orally active hepcidin production inhibitor with IC50 of 93 nM (hepcidin mRNA expression), shows serum hepcidin-lowering effects. |
| PC-22641 |
TAK-448
KISS1R agonist
|
TAK-448 (MVT-602) is a potent and full KISS1R (metastin receptor) agonist and kisspeptin analogue with IC50 of 3 pM in radioimmunoassay. |
| PC-22640 |
(S)-PHA533533
UBE3A unsilencer, CDK2 inhibitor
|
(S)-PHA533533 is a potent, small molecule unsilencer of paternal UBE3A in mouse primary neurons with EC50 of 0.54 uM, Emax=80%, effectively downregulates Ube3a-ATS/UBE3A ATS and epigenetically unsilences paternal Ube3a/UBE3A in both mouse and human neuron. |
| PC-22607 |
Orpinolide
OSBP inhibitor
|
Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface. |
| PC-22606 |
SABRAC
Acid ceramidase inhibitor
|
SABRAC is a highly potent, irreversible inhibitor of acid ceramidase (AC, aCDase) with Ki of 29.7 nM, induces apoptosis and provides a benefit in mice survival in IDH1 mut oligodendroglioma. |
| PC-22604 |
Oxybipin-2
OSBP inhibitor
|
Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking. |
| PC-22564 |
T-10418
GPR132 agonist
|
T-10418 is a potent, selective agonist of G protein-coupled receptor G2A (GPR132) with EC50 of 0.82 uM. |
| PC-22541 |
PSB-KK1445
GPR18 agonist
|
PSB-KK1445 is a potent and selective GPR18 agonist with EC50 of 45.4 nM and 124 nM for human and mouse GPR18, respectively, shows high selectivity versus related GPCRs CB1 and CB2, cannabinoid-like receptor, GPR55. |
| PC-22534 |
TSLP inhibitor BP79
TSLP inhibitor
|
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations. |
| PC-22494 |
CCG-1423
MKL1/SRF inhibitor
|
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer. |
